Gene: APBB2
Official Full Name: amyloid beta precursor protein binding family B member 2provided by HGNC
Gene Summary: The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38986 | APBB2 Knockout cell line (HeLa) | Human | APBB2 | 1:3~1:6 | Negative | Online Inquiry |
KO38987 | APBB2 Knockout cell line (HCT 116) | Human | APBB2 | 1:2~1:4 | Negative | Online Inquiry |
KO38988 | APBB2 Knockout cell line (HEK293) | Human | APBB2 | 1:3~1:6 | Negative | Online Inquiry |
KO38989 | APBB2 Knockout cell line (A549) | Human | APBB2 | 1:3~1:4 | Negative | Online Inquiry |
APBB2 Gene Knockout Cell Lines are genetically modified cell lines designed to have a targeted disruption of the APBB2 gene, which encodes a protein thought to play a significant role in various cellular processes, including synaptic function and cellular signaling pathways. By knocking out this specific gene, researchers can investigate the effects on cellular function and signaling cascades, thereby elucidating the contribution of APBB2 to biological systems.
The key function of APBB2 Gene Knockout Cell Lines lies in their application for studying gene function and regulation. The mechanism of action involves CRISPR/Cas9 or other genome editing technologies, which facilitate precise alterations to the genomic DNA, leading to the cessation of APBB2 protein production. As a result, the knockout cell lines serve as powerful tools for assessing the biological impact of APBB2 deficiency and provide insights into its role in diseases such as Alzheimer's and schizophrenia.
The scientific importance of these cell lines extends to both basic research and clinical applications. In research settings, they are invaluable for high-throughput screening of drug candidates, allowing scientists to explore potential therapeutics targeting pathways influenced by APBB2. Clinically, understanding the pathways downstream of APBB2 can pave the way for novel interventions in neurodegenerative diseases where this gene may be implicated.
Unlike conventional models, APBB2 Gene Knockout Cell Lines provide researchers with a tailored approach to investigate specific biological questions related to APBB2, yielding clear and reproducible results that are instrumental in translational research. Their specificity and reliability offer a considerable advantage over alternative models that may only give a broad overview without focusing on the gene of interest.
For researchers and clinicians aiming to deepen their understanding of the APBB2 gene and its implications, these cell lines represent an essential resource that can enhance experimental accuracy and biological relevance. Our company specializes in providing high-quality biological products, grounded in extensive biomolecular expertise, supporting the advancement of cutting-edge research and therapy solutions in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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