Gene: AP5Z1
Official Full Name: adaptor related protein complex 5 subunit zeta 1provided by HGNC
Gene Summary: This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32522 | AP5Z1 Knockout cell line (HeLa) | Human | AP5Z1 | 1:3~1:6 | Negative | Online Inquiry |
KO32523 | AP5Z1 Knockout cell line (HCT 116) | Human | AP5Z1 | 1:2~1:4 | Negative | Online Inquiry |
KO32524 | AP5Z1 Knockout cell line (HEK293) | Human | AP5Z1 | 1:3~1:6 | Negative | Online Inquiry |
KO32525 | AP5Z1 Knockout cell line (A549) | Human | AP5Z1 | 1:3~1:4 | Negative | Online Inquiry |
AP5Z1 Gene Knockout Cell Lines are a revolutionary biological tool designed to facilitate the study of the AP5Z1 gene and its associated pathways by providing a complete disruption of its function in a relevant cellular context. These knockout cell lines are generated through state-of-the-art CRISPR/Cas9 gene editing technology, which allows for precise and efficient genomic modifications, enabling researchers to observe and analyze the phenotypic effects resulting from the absence of the AP5Z1 gene.
The primary function of the AP5Z1 Gene Knockout Cell Lines is to serve as a robust model for investigating the physiological and pathological roles of the AP5Z1 protein. By elucidating the gene's mechanisms, researchers can explore critical cellular processes such as synaptic transmission and neurodevelopment, as well as its implications in various neurodegenerative diseases. Furthermore, the creation of these knockout lines ensures that researchers have access to consistent, reproducible, and well-characterized cell models that can be easily utilized in various high-throughput screening assays and mechanistic studies.
In terms of scientific importance, the AP5Z1 Gene Knockout Cell Lines can significantly accelerate the understanding of gene function in both fundamental biological research and applied clinical studies. They are particularly valuable in drug discovery efforts, where defining potential therapeutic targets is essential. The ability to manipulate and study these cells in a controlled environment allows for expedient validation of hypotheses and swift translation of findings into practical applications.
Unlike traditional cell models or other knockout technologies, AP5Z1 Gene Knockout Cell Lines boast high efficiency, specificity, and a lower likelihood of off-target effects due to the precision of CRISPR-based editing. This feature is crucial for researchers aiming to minimize variability in experimental outcomes. Additionally, they can be easily adapted for different experimental setups, rendering them a versatile choice for a wide audience from academic researchers to pharmaceutical companies.
For researchers and clinicians, the value of the AP5Z1 Gene Knockout Cell Lines lies not only in their advanced design but also in their contribution to pioneering insights and innovations in diseases related to the nervous system. With our extensive expertise in genetic engineering and cell line development, our company is dedicated to providing high-quality biological products that empower the scientific community to push the boundaries of research and ultimately improve human health.
Please note that all services are for research use only. Not intended for any clinical use.
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