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AP1S1 Knockout Cell Lines

Gene: AP1S1

Official Full Name: adaptor related protein complex 1 subunit sigma 1provided by HGNC

Gene Summary: The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00568 AP1S1 gRNA1-gRNA2 KO plasmid AP1S1 $850
KO00803 AP1S1 Knockout cell line(Hep G2) Human AP1S1 1:2~1:4 Negative Online Inquiry

Background

AP1S1 Gene Knockout Cell Lines represent a pioneering advancement in cellular research, designed to facilitate studying the functions and signaling pathways associated with the AP1S1 gene. AP1S1, known for its role in clathrin-mediated endocytosis, is vital for intracellular trafficking; thus, knockout models provide researchers with invaluable insights into membrane dynamics and disease mechanisms that involve dysregulation of endocytosis.

The key function of the AP1S1 gene knockout is its ability to create specific and targeted disruptions in gene expression, effectively disabling AP1S1 activity. This disruption leads to observable phenotypic changes that can reveal functional roles and consequences of the loss of AP1S1 in cellular processes. Utilizing CRISPR/Cas9 technology, these cell lines offer precise genetic modifications, resulting in high specificity and efficiency in gene disruption, making them a powerful tool for understanding the intricate biological roles of AP1S1.

The scientific importance of AP1S1 Gene Knockout Cell Lines extends across multiple research and clinical applications, including studies on cancer biology, neurological disorders, and metabolic diseases. By elucidating the pathways impacted by AP1S1 deficiencies, researchers can develop targeted therapies that address specific molecular dysfunctions, ultimately translating findings into clinical settings where understanding these pathways can lead to novel treatment strategies.

Compared to conventional cell line models, AP1S1 Gene Knockout Cell Lines offer distinct advantages. Their precision in gene editing ensures minimal off-target effects, yielding reproducible results crucial for experimental validation. Additionally, the availability of these knockout models enables standardized research conditions that facilitate cross-comparative studies, advancing scientific inquiries more effectively than existing products on the market.

For researchers and clinicians aiming to unlock the complexities of clathrin-mediated endocytosis and its implications in various pathologies, our AP1S1 Gene Knockout Cell Lines present an exceptional resource. Backed by our company's extensive expertise in genetic research tools and commitment to quality, we empower your research with innovative solutions that drive discovery and enhance understanding in the biosciences. Experience the next frontier in genetic analysis with our reliable and precise cell line offerings.

Please note that all services are for research use only. Not intended for any clinical use.

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