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AOC1 Knockout Cell Lines

Gene: AOC1

Official Full Name: amine oxidase copper containing 1provided by HGNC

Gene Summary: This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00017 AOC1 Knockout cell line (NK-92) Human AOC1 Negative Online Inquiry
KO39155 AOC1 Knockout cell line (HeLa) Human AOC1 1:3~1:6 Negative Online Inquiry

Background

AOC1 Gene Knockout Cell Lines represent a significant advancement in genetic research and cellular studies, specifically targeting the amine oxidase copper-containing 1 (AOC1) gene. These cell lines are genetically modified to eliminate the expression of the AOC1 gene, enabling researchers to more accurately study the biological functions and pathways associated with this enzyme, which is involved in various biological processes, including the metabolism of biogenic amines and the modulation of inflammatory responses.

The key function of AOC1 gene knockout cell lines lies in their ability to facilitate the elucidation of AOC1-associated mechanisms by allowing for controlled experimental conditions that isolate the influence of this gene. By comparing the knockout lines with wild-type cells, researchers can observe differences in cellular behavior, responsiveness to stimuli, and metabolic activities. This includes studying how the absence of AOC1 influences cell proliferation, apoptosis, and signal transduction pathways, thereby providing valuable insights into its role in pathological conditions such as cancer and neurodegenerative disorders.

The scientific relevance of AOC1 gene knockout cell lines extends into various research fields, including pharmacology, toxicology, and personalized medicine, where understanding the genetic basis of disease can lead to improved therapeutic strategies. In clinical settings, these cell lines can be utilized to screen for novel compounds that target AOC1-specific pathways, potentially leading to innovative treatments for conditions associated with its dysfunction.

What sets AOC1 gene knockout cell lines apart from alternative gene interference methods, such as transient knockdown approaches, is their stability and reproducibility. Researchers can conduct long-term studies without the variability associated with transient expression systems. This stability ensures a higher degree of confidence in experimental results, making these cell lines invaluable tools for rigorous scientific inquiry.

For researchers and clinicians seeking to deepen their understanding of AOC1's biological roles and its implications in health and disease, AOC1 gene knockout cell lines offer unparalleled opportunities for discovery and innovation. Our company is dedicated to advancing the field of genetic research, providing high-quality, validated cell lines, and harnessing our extensive expertise in molecular biology to support groundbreaking scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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