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ANO6 Knockout Cell Lines

Gene: ANO6

Official Full Name: anoctamin 6provided by HGNC

Gene Summary: This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00301 ANO6 Knockout cell line(HEK293) Human ANO6 1:3~1:6 Negative Online Inquiry
KO00504 ANO6 Knockout cell line (HeLa) Human ANO6 1:3~1:6 Negative Online Inquiry
KO01013 ANO6 Knockout cell line (293T) Human ANO6 1:3~1:6 Negative Online Inquiry
KO01263 ANO6 Knockout cell line (COS-1) Green monkey ANO6 1:3-1:4 Negative Online Inquiry
KO04948 ANO6 Knockout cell line (HCT 116) Human ANO6 1:2~1:4 Negative Online Inquiry
KO04949 ANO6 Knockout cell line (A549) Human ANO6 1:3~1:4 Negative Online Inquiry

Background

ANO6 Gene Knockout Cell Lines are genetically engineered cell lines that have undergone targeted editing to disrupt the expression of the ANO6 gene, which encodes for a protein involved in calcium-activated chloride channel activity. The mechanism by which these knockout lines operate hinges on the principle of homologous recombination or CRISPR-Cas9 technology, allowing precise modifications to the genomic structure. This disruption of ANO6 function facilitates researchers in studying its roles in various physiological and pathological contexts, particularly the regulation of intracellular calcium levels, cell death mechanisms, and potential implications in diseases such as cancer and cardiovascular disorders.

The scientific importance of ANO6 Gene Knockout Cell Lines lies in their broad applications across fundamental and applied biomedical research. These cell lines serve as invaluable tools for elucidating the specific functions of ANO6 in cellular processes and understanding how alterations in this gene contribute to disease pathways. In clinical settings, they provide a platform for the development of targeted therapies by allowing scientists to test the efficacy of new drugs aimed at modulating ANO6 activity.

One of the unique advantages of our ANO6 Gene Knockout Cell Lines over alternative models is their exceptional genetic fidelity and consistency, which ensure reproducibility in experimental results. Additionally, our product is available with detailed characterization data, guaranteeing that researchers can confidently interpret their findings.

For researchers and clinicians focused on exploring calcium signaling pathways, cellular responses to stress, or novel cancer therapeutics, the ANO6 Gene Knockout Cell Lines represent a pivotal resource that accelerates discovery while enabling precise functional analysis. Our company's unwavering commitment to innovation and excellence in biological products ensures that each cell line is developed under stringent quality controls, backed by our extensive expertise in genetic engineering and cell biology.

Please note that all services are for research use only. Not intended for any clinical use.

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