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ANKS1B Knockout Cell Lines

Gene: ANKS1B

Official Full Name: ankyrin repeat and sterile alpha motif domain containing 1Bprovided by HGNC

Gene Summary: This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09596 ANKS1B Knockout cell line (HEK293) Human ANKS1B 1:3~1:6 Negative Online Inquiry
KO09597 ANKS1B Knockout cell line (A549) Human ANKS1B 1:3~1:4 Negative Online Inquiry

Background

ANKS1B Gene Knockout Cell Lines are genetically engineered cell lines that have been modified to disrupt the ANKS1B gene, a key player involved in various cellular processes, including cytoskeleton organization, cell signaling, and metabolism. The knockout of this gene allows researchers to study the specific contributions of ANKS1B to these processes under controlled experimental conditions, providing insight into its role in health and disease.

The primary function of ANKS1B Gene Knockout Cell Lines is to facilitate the elucidation of gene function and gene interaction networks. By eliminating the expression of the ANKS1B protein, researchers can assess its impact on cellular behaviors such as proliferation, differentiation, and response to stimuli. This is particularly valuable in studies related to cancer research, neurological disorders, and metabolic diseases where ANKS1B is implicated. The mechanisms of action involve cellular pathways that are modulated by the presence or absence of ANKS1B, enabling targeted experiments to decipher its biological roles.

The scientific importance of these cell lines cannot be overstated, as they serve as powerful tools in both basic research and clinical applications. Their use extends to drug development, where understanding the molecular mechanisms may lead to novel therapeutic targets. In addition, these knockout lines can be employed in high-throughput screening assays, accelerating the discovery of new compounds that might affect pathways involving ANKS1B.

In comparison to conventional cell lines, ANKS1B Gene Knockout Cell Lines offer a unique advantage by providing a clean genetic background, eliminating confounding variables that can arise from residual gene activity. This specificity enhances the reproducibility and accuracy of experimental findings, making them indispensable for rigorous scientific inquiry.

For researchers and clinicians, the ability to manipulate and observe the effects of specific gene knockouts directly translates to more reliable data, allowing for better-informed decisions in experimental design and application. These cell lines are particularly appealing for those looking to explore gene function without the limitations posed by wild-type cellular responses.

Our company specializes in providing high-quality biological products engineered through advanced genetic technologies, ensuring that our offerings, like the ANKS1B Gene Knockout Cell Lines, meet the rigorous standards of the research community. By choosing our products, you are investing in reputable science that advances knowledge and supports breakthroughs across various fields.

Please note that all services are for research use only. Not intended for any clinical use.

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