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ANKRD13A Knockout Cell Lines

Gene: ANKRD13A

Official Full Name: ankyrin repeat domain 13Aprovided by HGNC

Gene Summary: Enables ubiquitin-modified protein reader activity. Involved in negative regulation of protein localization to endosome and negative regulation of receptor internalization. Located in late endosome; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24031 ANKRD13A Knockout cell line (HeLa) Human ANKRD13A 1:3~1:6 Negative Online Inquiry
KO24032 ANKRD13A Knockout cell line (HCT 116) Human ANKRD13A 1:2~1:4 Negative Online Inquiry
KO24033 ANKRD13A Knockout cell line (HEK293) Human ANKRD13A 1:3~1:6 Negative Online Inquiry
KO24034 ANKRD13A Knockout cell line (A549) Human ANKRD13A 1:3~1:4 Negative Online Inquiry

Background

ANKRD13A Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the expression of the ANKRD13A gene. This gene encodes a protein involved in various cellular processes, including endosomal trafficking and sensory pathway regulation, making its study crucial for understanding numerous biological mechanisms. The knockout of ANKRD13A allows researchers to investigate the gene's functional role, assess the impact of its absence on cellular behavior, and elucidate the pathways it influences.

These knockout cell lines operate via CRISPR-Cas9 technology, where specific guide RNAs are deployed to create double-strand breaks in the ANKRD13A gene, followed by the cellular repair mechanisms that result in frameshift mutations. This precise gene editing technique ensures that the resultant cell lines lack functional ANKRD13A, providing a valuable tool to study the consequences of gene loss on a range of cellular processes.

From a scientific perspective, ANKRD13A gene knockout cell lines have significant implications in research areas such as cancer biology, neurobiology, and immunology. Researchers can leverage these models to explore how the absence of ANKRD13A affects cell signaling, proliferation, and responses to external stimuli, with the potential for translational applications in disease modeling and therapeutic development.

What sets ANKRD13A gene knockout cell lines apart from similar products is their high specificity and reliability, ensuring that researchers achieve reproducible results in their studies. Furthermore, the comprehensive characterization provided alongside these cell lines ensures that users can readily confirm the success of the knockout and understand the underlying cellular contexts.

For researchers and clinicians seeking to delve into the molecular underpinnings of cell behavior and disease mechanisms, the ANKRD13A gene knockout cell lines are indispensable. As an offering from our company, which specializes in precision genetic engineering and cutting-edge biotechnological solutions, you can trust that our products are backed by extensive expertise and a commitment to quality and innovation in the life sciences field.

Please note that all services are for research use only. Not intended for any clinical use.

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