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ANK3 Knockout Cell Lines

Gene: ANK3

Official Full Name: ankyrin 3provided by HGNC

Gene Summary: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20533 ANK3 Knockout cell line (HeLa) Human ANK3 1:3~1:6 Negative Online Inquiry
KO20534 ANK3 Knockout cell line (HCT 116) Human ANK3 1:2~1:4 Negative Online Inquiry
KO20535 ANK3 Knockout cell line (HEK293) Human ANK3 1:3~1:6 Negative Online Inquiry
KO20536 ANK3 Knockout cell line (A549) Human ANK3 1:3~1:4 Negative Online Inquiry

Background

ANK3 Gene Knockout Cell Lines represent a revolutionary tool in molecular biology, specifically designed to facilitate the study of the ankyrin 3 (ANK3) gene, which plays a critical role in the organization of membrane proteins and neuronal function. These cell lines are genetically engineered to lack functional ANK3, providing researchers with a valuable model for investigating the gene’s implications in various biological processes, including synaptic signaling and neuropsychiatric disorders.

The key function of these knockout cell lines is to enable the exploration of ANK3's role in cellular activities, particularly in neurons where it is critically involved in neuronal excitability and signal transmission. By understanding how the absence of ANK3 affects cellular behavior, researchers can elucidate the underlying mechanisms of related pathologies, such as bipolar disorder, schizophrenia, and other neurodevelopmental conditions. The creation of these knockout cell lines is executed using advanced CRISPR-Cas9 technology, ensuring precise modifications and high efficiency.

The scientific importance of ANK3 Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, they facilitate the dissection of molecular pathways influenced by ANK3, which can lead to the identification of novel therapeutic targets. Clinically, insights gained from these models have the potential to inform treatment strategies for mental health disorders, enhancing our understanding of their etiology.

What sets these knockout cell lines apart from alternatives is their specificity and reliability. Unlike transient knockdown techniques, which may result in incomplete gene inhibition, the knockout approach allows for stable and permanent alterations in the cell line. Additionally, these cell lines can be rapidly expanded and characterized, providing a consistent experimental substrate for a variety of assays.

The value of ANK3 Gene Knockout Cell Lines lies in their ability to provide a clear and reproducible model for testing hypotheses related to ANK3 function and its involvement in disease. Researchers and clinicians will find these tools indispensable for advancing their understanding of complex genetic interactions and for developing targeted therapies.

Our company boasts extensive experience in the development and production of genetically engineered cell lines, ensuring that our products meet the highest standards of quality and innovation. By choosing ANK3 Gene Knockout Cell Lines, users are not just purchasing a product; they are investing in cutting-edge research capabilities backed by expert-driven support and scientific excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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