Gene: AMOTL1
Official Full Name: angiomotin like 1provided by HGNC
Gene Summary: The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06609 | AMOTL1 Knockout cell line (HeLa) | Human | AMOTL1 | 1:3~1:6 | Negative | Online Inquiry |
KO06610 | AMOTL1 Knockout cell line (HCT 116) | Human | AMOTL1 | 1:2~1:4 | Negative | Online Inquiry |
KO06611 | AMOTL1 Knockout cell line (HEK293) | Human | AMOTL1 | 1:3~1:6 | Negative | Online Inquiry |
KO06612 | AMOTL1 Knockout cell line (A549) | Human | AMOTL1 | 1:3~1:4 | Negative | Online Inquiry |
AMOTL1 Gene Knockout Cell Lines represent a revolutionary tool in molecular biology and genetic research designed to enable the study of the Angiomotin-like 1 (AMOTL1) gene's role in cellular functions. These specialized cell lines have been engineered through precise gene editing techniques, such as CRISPR/Cas9, to effectively disrupt the AMOTL1 gene, which plays a critical role in cellular adhesion, proliferation, and differentiation. By eliminating AMOTL1 expression, researchers can investigate the downstream effects on various cellular pathways, providing insights into its contribution to processes such as angiogenesis and tumorigenesis.
The core mechanism behind these knockout cell lines lies in their ability to mimic specific genetic disorders or aberrations found in various diseases, facilitating in-depth studies of the AMOTL1 gene's functionality. This enables scientists to explore its interactions with other genes, proteins, and signaling pathways, thereby unraveling complex biological networks. In clinical settings, these insights may lead to the identification of novel therapeutic targets for diseases associated with dysregulated angiogenesis, such as cancers and cardiovascular conditions.
One of the significant advantages of AMOTL1 Gene Knockout Cell Lines is their high degree of specificity and reproducibility. Unlike other models that may present off-target effects, these engineered lines deliver consistent and reliable data, making them an ideal choice for rigorous experimental designs. Furthermore, they allow for the exploration of disease mechanisms without the ethical concerns associated with animal models, aligning with the principles of 3Rs (Reduce, Refine, Replace).
Researchers and clinicians can benefit immensely from the unique capabilities of AMOTL1 Gene Knockout Cell Lines. By incorporating these models into their investigations, users can enhance the validity of their experimental findings and accelerate the development of innovative therapeutic strategies. The insights derived from studies using these cell lines could ultimately lead to transformative advancements in personalized medicine.
Our company specializes in providing high-quality biological products, underpinned by extensive expertise in gene editing technologies. We are committed to delivering state-of-the-art tools like the AMOTL1 Gene Knockout Cell Lines to empower researchers and clinicians in their pursuit of groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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