Gene: AMH
Official Full Name: anti-Mullerian hormoneprovided by HGNC
Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08497 | AMH Knockout cell line (HeLa) | Human | AMH | 1:3~1:6 | Negative | Online Inquiry |
KO08498 | AMH Knockout cell line (HCT 116) | Human | AMH | 1:2~1:4 | Negative | Online Inquiry |
KO08499 | AMH Knockout cell line (HEK293) | Human | AMH | 1:3~1:6 | Negative | Online Inquiry |
KO08500 | AMH Knockout cell line (A549) | Human | AMH | 1:3~1:4 | Negative | Online Inquiry |
AMH Gene Knockout Cell Lines are meticulously engineered cell lines in which the Anti-Müllerian Hormone (AMH) gene has been disrupted or knocked out. This genetic modification enables researchers to study the biological effects of AMH across various cellular contexts. AMH plays a crucial role in sexual differentiation and reproductive health, particularly in regulating ovarian function and inhibiting excess folliculogenesis. By utilizing these knockout cell lines, scientists can investigate the mechanistic pathways affected by AMH deficiency, explore the gene's involvement in reproductive disorders, and elucidate broader implications for fertility research and related endocrine functions.
The key function of AMH Gene Knockout Cell Lines lies in their ability to model conditions that involve AMH signaling pathways. Researchers can utilize these cell lines to perform functional assays that analyze hormone responsiveness, cellular signaling cascades, and gene expression changes that occur in AMH-deficient environments. Furthermore, these cell lines facilitate the examination of drug interactions and potential therapeutic interventions aimed at restoring normal AMH signaling.
The significance of AMH Gene Knockout Cell Lines extends beyond basic research; they are invaluable in clinical settings for understanding infertility, polycystic ovary syndrome (PCOS), and other reproductive endocrine disorders. With increasing focus on personalized medicine, these cell lines enable researchers to dissect patient-specific variations and therapeutic responses, fostering the development of tailored treatment options.
Compared to traditional wild-type cell lines, our AMH Gene Knockout Cell Lines provide a robust tool for studying the direct consequences of AMH signaling disruption. This specific genetic modification leads to enhanced experimental precision and reduces the confounding effects often observed with non-targeted approaches. Our product is ideal for researchers aiming to innovate in the fields of reproductive biology and endocrinology, presenting a clear path to advancing scientific knowledge and therapeutic strategies.
The expertise of our company in genetic engineering and cell line development underpins the reliability and quality of the AMH Gene Knockout Cell Lines, ensuring that customers receive top-tier products backed by rigorous scientific validation. By choosing our product, users are empowered to make significant strides in their research endeavors with the assurance of enhanced specificity and reproducibility.
Please note that all services are for research use only. Not intended for any clinical use.
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