Gene: ALX4
Official Full Name: ALX homeobox 4provided by HGNC
Gene Summary: This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, cognitive disability, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20296 | ALX4 Knockout cell line (HEK293) | Human | ALX4 | 1:3~1:6 | Negative | Online Inquiry |
ALX4 Gene Knockout Cell Lines are specifically engineered mammalian cell lines that have been genetically modified to exhibit a complete knockout of the ALX4 gene. This innovative product allows researchers to study the functional implications of ALX4 gene deletion, effectively facilitating the investigation into a variety of biological processes, including developmental biology, cell signaling pathways, and the molecular mechanisms underlying skeletal disorders.
The primary function of these knockout cell lines resides in their ability to serve as a robust model system for understanding the gene's role in physiological and pathological contexts. The absence of the ALX4 gene enables researchers to analyze the resultant phenotypic changes, alterations in gene expression profiles, and the downstream signaling cascades that may be affected. This is particularly pivotal in elucidating the gene's contributions to specific cellular processes, such as migration, differentiation, and proliferative responses.
From a scientific standpoint, ALX4 Gene Knockout Cell Lines hold significant promise for both research and clinical applications. By using this innovative tool, scientists can gain deeper insights into the gene's involvement in various diseases, thereby aiding in the discovery of potential therapeutic targets. These cell lines have particular relevance in studies related to osteoarthritis, congenital skeletal deformities, and other conditions where ALX4 is implicated.
What sets ALX4 Gene Knockout Cell Lines apart from other alternatives is their high specificity and reliability. They are developed using state-of-the-art CRISPR/Cas9 technology, ensuring precise genome editing with minimal off-target effects. Furthermore, these cell lines have undergone rigorous validation, providing researchers with confidence in their reproducibility and biological relevance.
For researchers and clinicians, the value of using ALX4 Gene Knockout Cell Lines lies in their ability to simplify complex genetic studies while delivering actionable insights into gene function. With these knockout models, users can accelerate their research timelines and enhance the quality of their findings.
Our company specializes in providing high-quality biological research tools designed to empower the scientific community. With expertise in genetic engineering and a commitment to excellence, we are dedicated to offering innovative products that support transformative research across various fields.
Please note that all services are for research use only. Not intended for any clinical use.
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