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ALDH9A1 Knockout Cell Lines

Gene: ALDH9A1

Official Full Name: aldehyde dehydrogenase 9 family member A1provided by HGNC

Gene Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO39041 ALDH9A1 Knockout cell line (HeLa) Human ALDH9A1 1:3~1:6 Negative Online Inquiry
KO39042 ALDH9A1 Knockout cell line (HCT 116) Human ALDH9A1 1:2~1:4 Negative Online Inquiry
KO39043 ALDH9A1 Knockout cell line (HEK293) Human ALDH9A1 1:3~1:6 Negative Online Inquiry
KO39044 ALDH9A1 Knockout cell line (A549) Human ALDH9A1 1:3~1:4 Negative Online Inquiry

Background

ALDH9A1 Gene Knockout Cell Lines are engineered cellular models that feature a precise knockout of the aldehyde dehydrogenase 9A1 (ALDH9A1) gene. This genetic alteration offers researchers a powerful tool to study the role of ALDH9A1 in various biochemical pathways and its implications in metabolic disorders and neurodegenerative diseases. ALDH9A1 is involved in the metabolism of neurotoxic aldehydes and is essential for the detoxification processes within cells, making it pivotal for understanding oxidative stress responses in human health.

The mechanism of action for these knockout cell lines involves the complete disruption of the ALDH9A1 gene, leading to diminished enzymatic activity that can be quantitatively analyzed. Researchers can observe consequent alterations in metabolic flux, cellular stress responses, and signaling pathways associated with aldehyde detoxification. This innovative model allows for the evaluation of potential therapeutic strategies aimed at mitigating the effects of ALDH9A1 deficiency, shedding light on its contributions to various disease states.

From a scientific standpoint, the ALDH9A1 Gene Knockout Cell Lines are invaluable for preclinical studies, platform development for drug discovery, and elucidating disease mechanisms. Their utility spans research applications in cancer biology, neurobiology, and pharmacology, facilitating important discoveries related to enzymatic roles in human diseases.

What sets our ALDH9A1 Gene Knockout Cell Lines apart from alternative models is the robustness and specificity of the knockout, which ensures high fidelity in research outcomes. Furthermore, our product undergoes rigorous quality assurance testing to guarantee reproducibility, an essential criterion for cutting-edge scientific studies.

Researchers and clinicians alike will find this product to be an indispensable asset in their endeavors to advance knowledge and develop novel therapies. The ability to manipulate gene expression in a controlled environment opens new avenues in biomedical research, enabling breakthroughs that may ultimately benefit patients.

With a commitment to pioneering biological research tools, our company fosters innovation through meticulously developed cell lines, reinforcing our dedication to enhancing the capabilities of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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