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AKR7A2 Knockout Cell Lines

Gene: AKR7A2

Official Full Name: aldo-keto reductase family 7 member A2provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34034 AKR7A2 Knockout cell line (HeLa) Human AKR7A2 1:3~1:6 Negative Online Inquiry
KO34035 AKR7A2 Knockout cell line (HCT 116) Human AKR7A2 1:2~1:4 Negative Online Inquiry
KO34036 AKR7A2 Knockout cell line (HEK293) Human AKR7A2 1:3~1:6 Negative Online Inquiry
KO34037 AKR7A2 Knockout cell line (A549) Human AKR7A2 1:3~1:4 Negative Online Inquiry

Background

AKR7A2 Gene Knockout Cell Lines are a specialized tool designed for advanced biological research, specifically targeting the AKR7A2 gene, which is involved in various metabolic processes and is crucial for understanding its role in human diseases. By utilizing CRISPR-Cas9 technology, these cell lines feature the knockout of the AKR7A2 gene, allowing researchers to study the gene's functional contributions to cellular metabolism, stress responses, and potential implications in metabolic disorders.

The primary function of the AKR7A2 Gene Knockout Cell Lines is to provide a versatile platform for examining the downstream effects of AKR7A2 depletion. These engineered cell lines facilitate the activation of various signaling pathways, enabling researchers to dissect the molecular mechanisms underlying disease processes, drug interactions, and metabolic regulation. The absence of the AKR7A2 gene allows for comparative analyses, fostering insights into compensatory mechanisms or altered cellular behaviors that may arise from its knockout.

From a scientific and clinical perspective, these cell lines hold immense value in research settings, particularly in pharmacology, toxicology, and metabolic disease studies. They serve as critical models for screening potential drug candidates, investigating therapeutic targets, and understanding disease pathology, significantly impacting translational research efforts.

Compared to traditional knockout models, the AKR7A2 Gene Knockout Cell Lines offer unique advantages, including faster generation times, precise gene editing efficiency, and reduced off-target effects. This precision ensures that researchers can obtain reliable and reproducible data, essential for robust experimental validation.

For researchers, clinicians, and organizations committed to advancing healthcare, the AKR7A2 Gene Knockout Cell Lines represent a valuable resource for driving innovation and discovery. Our company is dedicated to providing high-quality, cutting-edge biological products to support the scientific community's ongoing pursuit of knowledge, with a strong emphasis on accuracy, reliability, and accessibility in laboratory settings.

Please note that all services are for research use only. Not intended for any clinical use.

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