Gene: AKAP10
Official Full Name: A-kinase anchoring protein 10provided by HGNC
Gene Summary: This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31069 | AKAP10 Knockout cell line (HeLa) | Human | AKAP10 | 1:3~1:6 | Negative | Online Inquiry |
KO31070 | AKAP10 Knockout cell line (HCT 116) | Human | AKAP10 | 1:2~1:4 | Negative | Online Inquiry |
KO31071 | AKAP10 Knockout cell line (HEK293) | Human | AKAP10 | 1:3~1:6 | Negative | Online Inquiry |
KO31072 | AKAP10 Knockout cell line (A549) | Human | AKAP10 | 1:3~1:4 | Negative | Online Inquiry |
AKAP10 Gene Knockout Cell Lines represent a pioneering advancement in the realm of genetic research, specifically focused on dissecting the complex interactions within cellular signaling pathways. These specialized cell lines have been engineered to lack the expression of the AKAP10 gene, which encodes A-kinase anchoring protein 10, known for its pivotal role in the spatial regulation of protein kinase A (PKA) and involvement in various cellular processes, including signal transduction, cell proliferation, and apoptosis.
The primary function of AKAP10 is to facilitate the targeted anchoring of PKA to specific intracellular locations, thereby coordinating the precise phosphorylation of substrates involved in critical cellular functions. By utilizing AKAP10 Gene Knockout Cell Lines, researchers can obtain invaluable insights into the regulatory networks governed by PKA, as well as the downstream effects on cellular behaviors such as differentiation and stress responses. This aids in understanding the pathological mechanisms underlying various diseases, including cancer and cardiovascular disorders.
In the realm of research and clinical applications, the significance of these knockout cell lines cannot be overstated. They serve as robust models for investigating the consequences of AKAP10 deficiency, assisting scientists in the identification of novel therapeutic targets and biomarkers. Moreover, the ability to study the loss of function of AKAP10 enables more in-depth exploration of signal transduction pathways, offering the potential for the development of targeted therapies.
What sets our AKAP10 Gene Knockout Cell Lines apart from alternatives is their rigorous validation and optimal background system, ensuring high specificity and reliability in experiments. These cell lines are prepared with cutting-edge CRISPR/Cas9 technology, making them not only precise but also amenable to various experimental setups. They offer researchers a refined tool for elucidating the nuances of cellular signaling without the confounding effects often seen in less specialized models.
Investing in AKAP10 Gene Knockout Cell Lines provides researchers and clinicians with unparalleled access to state-of-the-art technology, facilitating groundbreaking discoveries within cellular biology. Our commitment to quality and innovation in biological products ensures that customers receive the most relevant and effective tools for their scientific exploration. With extensive expertise in gene editing technologies, our company stands at the forefront of advancing research capabilities, empowering scientists to push the boundaries of knowledge in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
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