Gene: AK1
Official Full Name: adenylate kinase 1provided by HGNC
Gene Summary: This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene shares readthrough transcripts with the upstream ST6GALNAC6 gene. [provided by RefSeq, Jan 2022]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03476 | AK1 Knockout cell line (HeLa) | Human | AK1 | 1:3~1:6 | Negative | Online Inquiry |
KO03477 | AK1 Knockout cell line (HCT 116) | Human | AK1 | 1:2~1:4 | Negative | Online Inquiry |
KO03478 | AK1 Knockout cell line (HEK293) | Human | AK1 | 1:3~1:6 | Negative | Online Inquiry |
KO03479 | AK1 Knockout cell line (A549) | Human | AK1 | 1:3~1:4 | Negative | Online Inquiry |
AK1 Gene Knockout Cell Lines are specifically engineered cellular systems designed to facilitate the study of the AK1 gene's functions and regulatory networks. Utilizing the CRISPR-Cas9 genome editing technology, these cell lines boast precise modifications leading to the deletion of the AK1 gene, allowing researchers to evaluate the physiological and biochemical consequences of its absence in a controlled environment.
The primary function of AK1 Gene Knockout Cell Lines is to serve as a robust platform for investigating the roles of AK1 in various cellular processes, including energy metabolism, cell proliferation, and apoptosis. By eliminating the gene's expression, researchers can monitor downstream effects on gene expression profiles, metabolic fluxes, and overall cell viability. This mechanistic insight is crucial for understanding disease pathology, particularly in cancer where energy metabolism is significantly altered.
The scientific importance of these knockout cell lines extends to a wide range of applications within molecular biology and pharmacology. They can be invaluable in drug discovery pipelines, helping to screen compounds that may target the AK1 pathway, or as models for studying metabolic disorders and other conditions linked to aberrant energy regulation. In clinical settings, insights gained from these models can inform the development of novel therapeutic strategies aimed at mitigating the impacts of AK1 dysregulation.
Compared to other genetic manipulation techniques, the AK1 Gene Knockout Cell Lines offer unparalleled specificity and efficiency, minimizing off-target effects typical of traditional RNAi approaches or earlier gene targeting methodologies. Their ease of use and reproducibility make them an attractive option for laboratories committed to high-quality, reliable results.
For researchers and clinicians alike, the value of AK1 Gene Knockout Cell Lines lies in their ability to generate meaningful data that can advance understanding of key biological processes and contribute to transformative research outcomes. With a dedicated focus on enhancing scientific discovery, our company brings expertise in the development of high-quality biological products, ensuring that our customers have access to cutting-edge tools necessary for achieving their research goals.
Please note that all services are for research use only. Not intended for any clinical use.
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