Gene: AIMP1
Official Full Name: aminoacyl tRNA synthetase complex interacting multifunctional protein 1provided by HGNC
Gene Summary: The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33404 | AIMP1 Knockout cell line (HeLa) | Human | AIMP1 | 1:3~1:6 | Negative | Online Inquiry |
KO33405 | AIMP1 Knockout cell line (HCT 116) | Human | AIMP1 | 1:2~1:4 | Negative | Online Inquiry |
KO33406 | AIMP1 Knockout cell line (HEK293) | Human | AIMP1 | 1:3~1:6 | Negative | Online Inquiry |
KO33407 | AIMP1 Knockout cell line (A549) | Human | AIMP1 | 1:3~1:4 | Negative | Online Inquiry |
AIMP1 Gene Knockout Cell Lines are specialized cellular models developed to facilitate comprehensive studies on the role of the AIMP1 gene, which encodes a crucial protein involved in various cellular processes, including aminoacylation and immune response modulation. By effectively disrupting the AIMP1 gene, these knockout cell lines provide researchers with invaluable tools to investigate the molecular mechanisms underpinning cellular behavior in both normal and pathological conditions.
The key function of AIMP1 involves its role as a scaffolding protein that interacts with various components of the multi-tRNA synthetase complex, contributing to the synthesis of amino acids crucial for protein translation and cellular metabolism. The knockout of this gene leads to significant alterations in these processes, allowing scientists to dissect the implications of AIMP1 deficiency in a range of biological contexts, including cancer progression, inflammatory responses, and neurodegenerative diseases.
From a scientific standpoint, these cell lines hold immense importance in both research and clinical applications, offering insights into gene function, protein interactions, and cell signaling pathways. They serve as excellent models for drug discovery and development, especially for targeting diseases where AIMP1 is implicated. By enhancing our understanding of its biological roles, researchers can potentially identify novel therapeutic avenues, making these cell lines essential for innovative biomedical research.
What sets AIMP1 Gene Knockout Cell Lines apart from competitors is their rigorously validated genetic modifications and their ready availability in multiple relevant cell types, which allows for flexible experimental design. Furthermore, their performance has been optimized to ensure reproducibility and reliability of results, giving researchers confidence in their findings.
For researchers and clinicians, these cell lines present a golden opportunity to deepen their understanding of cellular mechanisms and translate discoveries into clinical applications. By utilizing AIMP1 Gene Knockout Cell Lines, target users not only advance their research but also contribute to the development of targeted therapies that may improve patient outcomes.
Our company has extensive expertise in producing high-quality biological products and is dedicated to supporting scientific advancement through innovative solutions tailored to the needs of researchers and clinicians alike.
Please note that all services are for research use only. Not intended for any clinical use.
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