Gene: AHI1
Official Full Name: Abelson helper integration site 1provided by HGNC
Gene Summary: This gene is apparently required for both cerebellar and cortical development in humans. This gene mutations cause specific forms of Joubert syndrome-related disorders. Joubert syndrome (JS) is a recessively inherited developmental brain disorder with several identified causative chromosomal loci. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19920 | AHI1 Knockout cell line (HeLa) | Human | AHI1 | 1:3~1:6 | Negative | Online Inquiry |
KO19921 | AHI1 Knockout cell line (HCT 116) | Human | AHI1 | 1:2~1:4 | Negative | Online Inquiry |
KO19922 | AHI1 Knockout cell line (HEK293) | Human | AHI1 | 1:3~1:6 | Negative | Online Inquiry |
KO19923 | AHI1 Knockout cell line (A549) | Human | AHI1 | 1:3~1:4 | Negative | Online Inquiry |
AHI1 Gene Knockout Cell Lines are advanced biological research tools specifically engineered to facilitate the study of the AHI1 gene, which is implicated in various neurological disorders and developmental processes. These cell lines are derived from established human or animal cell cultures, where the AHI1 gene has been intentionally disrupted or "knocked out" using precise gene-editing techniques such as CRISPR/Cas9. This targeted knockout enables researchers to investigate the direct effects of AHI1 deficiency, providing insights into the gene's role in cellular functions, signal transduction pathways, and contributions to disease phenotypes.
The mechanism by which these cell lines function hinges on the absence of AHI1 protein, allowing for the observation of downstream effects that may result from its loss. This study may reveal altered pathways in neurogenesis, synaptic function, and cellular homeostasis, facilitating a deeper understanding of disorders like Joubert syndrome and other neurodevelopmental conditions associated with AHI1 mutations.
In scientific research and clinical applications, AHI1 Gene Knockout Cell Lines are essential for modeling human diseases, screening potential therapeutics, and validating genetic interactions. Their precise gene editing ensures that findings are relevant and applicable to human health, which is invaluable in developing new strategies for intervention.
What sets AHI1 Gene Knockout Cell Lines apart from traditional knockout methods is their reliability, reproducibility, and the speed with which researchers can obtain results, minimizing experimental variability. These lines also offer a higher degree of specificity in gene editing, reducing off-target effects that could confound results.
For researchers and clinicians alike, the availability of AHI1 Gene Knockout Cell Lines represents an invaluable resource, enabling groundbreaking studies that can advance our understanding of genetic disorders and propel therapeutic discovery. Our company prides itself on its expertise in genetic engineering, offering high-quality, well-characterized cell lines that are indispensable for the next generation of biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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