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AGFG2 Knockout Cell Lines

Gene: AGFG2

Official Full Name: ArfGAP with FG repeats 2provided by HGNC

Gene Summary: This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37192 AGFG2 Knockout cell line (HeLa) Human AGFG2 1:3~1:6 Negative Online Inquiry
KO37193 AGFG2 Knockout cell line (HCT 116) Human AGFG2 1:2~1:4 Negative Online Inquiry
KO37194 AGFG2 Knockout cell line (HEK293) Human AGFG2 1:3~1:6 Negative Online Inquiry
KO37195 AGFG2 Knockout cell line (A549) Human AGFG2 1:3~1:4 Negative Online Inquiry

Background

AGFG2 Gene Knockout Cell Lines are highly specialized biological resources that have been engineered to lack the expression of the AGFG2 gene, a key player in various cellular processes such as membrane trafficking, autophagy, and growth factor signaling. These cell lines serve as vital tools for researchers seeking to investigate the functional consequences of AGFG2 deficiency, elucidating its role in pathophysiological conditions and various diseases, including cancer and neurodegenerative disorders.

The knockout mechanism of these cell lines is achieved through precise gene-editing technologies, such as CRISPR/Cas9, which introduce targeted deletions within the AGFG2 gene, resulting in a non-functional protein. This allows researchers to study cellular responses to AGFG2 loss, providing insights into its biological functions and interactions within signaling pathways. Researchers can utilize these cell lines to perform a variety of assays, including proliferation, migration, and apoptosis studies, critical for identifying novel therapeutic targets.

In the scientific community, the AGFG2 Gene Knockout Cell Lines are especially valuable due to their specificity and reproducibility. They offer a refined alternative to traditional methods such as pharmacological inhibition, which can present off-target effects and variability. The use of these knockout models improves the accuracy of experimental outcomes, allowing for a deeper understanding of AGFG2's role in cellular mechanisms.

For researchers and clinicians, the advantages of using AGFG2 Gene Knockout Cell Lines lie in their potential to bridge the gap between basic research and clinical applications. By enabling the identification of biomarkers and therapeutic targets associated with AGFG2-related pathways, these cell lines can contribute to the development of innovative treatments. Moreover, their availability enhances research efficiency and supports reproducibility across studies.

Our company specializes in providing high-quality biological products, backed by years of expertise in cell line engineering and genetics. We are committed to supporting the scientific community with cutting-edge tools that spur advancements in research and therapeutic applications. Through our AGFG2 Gene Knockout Cell Lines, we aim to facilitate groundbreaking discoveries that may improve human health and disease management.

Please note that all services are for research use only. Not intended for any clinical use.

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