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AGAP1 Knockout Cell Lines

Gene: AGAP1

Official Full Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1provided by HGNC

Gene Summary: This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02936 AGAP1 Knockout cell line (HeLa) Human AGAP1 1:3~1:6 Negative Online Inquiry
KO02937 AGAP1 Knockout cell line (HCT 116) Human AGAP1 1:2~1:4 Negative Online Inquiry
KO02938 AGAP1 Knockout cell line (HEK293) Human AGAP1 1:3~1:6 Negative Online Inquiry
KO02939 AGAP1 Knockout cell line (A549) Human AGAP1 1:3~1:4 Negative Online Inquiry

Background

AGAP1 Gene Knockout Cell Lines are genetically modified cellular models specifically designed to study the functional implications of the AGAP1 gene, which is involved in various cellular processes, including signal transduction and membrane trafficking. By employing CRISPR/Cas9 gene-editing technology, these cell lines achieve a precise deletion of the AGAP1 gene, allowing researchers to investigate the effects of its absence on cellular behavior, interactions, and associated pathways.

The primary function of AGAP1 is its role as a GTPase-activating protein for ARF GTPases, crucial in regulating endocytic and secretory pathways within the cell. Through the knockout of the AGAP1 gene, researchers can elucidate its impact on cellular processes such as vesicle formation and intracellular transport. This facilitates the exploration of AGAP1's involvement in pathologies linked to dysregulated cellular mechanisms, including cancer and neurodegenerative diseases.

Scientifically, AGAP1 Gene Knockout Cell Lines serve as indispensable tools in both academic and clinical settings. They not only provide insights into fundamental biological processes but also have significant implications for the development of targeted therapies. Understanding AGAP1's role can lead to novel therapeutic strategies for conditions where its regulatory function is compromised.

Compared to alternative models, such as wild-type or knockdown variants, AGAP1 Gene Knockout Cell Lines offer a comprehensive evaluation of loss-of-function phenotypes, presenting a distinct advantage in experimental rigor. These cell lines are rigorously characterized, ensuring the validity and reproducibility of experimental outcomes, which are critical for advancing research.

For researchers and clinicians seeking to explore the complex role of AGAP1 in various biological contexts, AGAP1 Gene Knockout Cell Lines are an invaluable asset. They enable a deeper understanding of gene function, disease mechanisms, and the potential for therapeutic innovation.

At [Your Company Name], we are committed to providing cutting-edge biological products and resources that enable scientific discovery and innovation. Our expertise in genetic engineering ensures the highest quality and reliability in our cell line offerings, empowering researchers to advance their work with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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