Gene: AFG1L
Official Full Name: AFG1 like ATPaseprovided by HGNC
Gene Summary: This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21483 | AFG1L Knockout cell line (HeLa) | Human | AFG1L | 1:3~1:6 | Negative | Online Inquiry |
KO21484 | AFG1L Knockout cell line (HCT 116) | Human | AFG1L | 1:2~1:4 | Negative | Online Inquiry |
KO21485 | AFG1L Knockout cell line (HEK293) | Human | AFG1L | 1:3~1:6 | Negative | Online Inquiry |
KO21486 | AFG1L Knockout cell line (A549) | Human | AFG1L | 1:3~1:4 | Negative | Online Inquiry |
AFG1L Gene Knockout Cell Lines are genetically modified cell lines where the AFG1L gene has been selectively inactivated or "knocked out." This genetic modification allows researchers to investigate the functions of the AFG1L gene and its role in cellular processes. AFG1L, implicated in various signaling pathways and cellular responses, plays a crucial role in understanding the mechanisms of diseases, particularly in neurobiology and cancer research.
The primary function of these knockout cell lines is to elucidate the biological impacts of AFG1L depletion. By comparing the behavior of AFG1L knockout cells to wild-type counterparts, scientists can analyze alterations in cell proliferation, differentiation, and response to stress or stimuli. The absence of AFG1L provides insights into compensatory mechanisms activated by cells, thereby enhancing our understanding of genetic redundancy and pathway activation in complex biological systems.
The scientific importance of AFG1L knockout cell lines extends into both research and clinical applications. In research, these cell lines serve as powerful tools to model human diseases and study mutation effects, paving the way for targeted therapies. In clinical settings, understanding AFG1L's role could lead to breakthrough treatments for conditions that exhibit dysregulated AFG1L expression.
Compared to alternative methods such as RNA interference or transient transfection, which provide temporary gene silencing, AFG1L gene knockout cell lines offer a stable model for long-term studies and high-throughput screening. This permanence allows for more consistent experimental conditions and reproducibility, making them invaluable for longitudinal research.
Researchers and clinicians will find AFG1L Gene Knockout Cell Lines particularly valuable due to their potential to provide definitive answers regarding gene function and its implications in pathology. Additionally, these lines enhance the predictive power of experiments, potentially leading to significant advancements in therapeutic strategies.
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Please note that all services are for research use only. Not intended for any clinical use.
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