Gene: ADRM1
Official Full Name: ADRM1 26S proteasome ubiquitin receptorprovided by HGNC
Gene Summary: This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00444 | ADRM1 gRNA1-gRNA2 KO plasmid | ADRM1 | $850 | |||
KO00740 | ADRM1 Knockout cell line (HeLa) | Human | ADRM1 | 1:3~1:6 | Negative | Online Inquiry |
KO19969 | ADRM1 Knockout cell line (HCT 116) | Human | ADRM1 | 1:2~1:4 | Negative | Online Inquiry |
KO19970 | ADRM1 Knockout cell line (HEK293) | Human | ADRM1 | 1:3~1:6 | Negative | Online Inquiry |
ADRM1 Gene Knockout Cell Lines are specialized cell lines that have undergone precise genetic modification to inactivate the ADRM1 gene, which plays a crucial role in various cellular processes including proteasomal degradation and DNA repair. By knocking out this gene, researchers can study the downstream effects on cellular functions and elucidate the role of ADRM1 in disease models, particularly in cancer, where the protein's modulation of the cell cycle and apoptosis is of significant interest.
The primary mechanism of these cell lines involves the use of CRISPR-Cas9 or similar gene-editing technologies to ensure accurate and complete disruption of the ADRM1 gene. This allows for the investigation of gene function without the confounding effects of ADRM1 activity, thereby facilitating a clearer understanding of its biological pathways and potential interactions with other cellular components.
Scientifically, ADRM1 Gene Knockout Cell Lines are invaluable tools in both research and clinical settings. They allow scientists to dissect the molecular functions of ADRM1, paving the way for developments in therapeutic strategies targeting its associated pathways. In cancer research, for instance, understanding how the loss of ADRM1 affects tumorigenesis can lead to novel approaches in treatment and prevention.
What sets these cell lines apart from alternative models is their high fidelity in gene knockout, consistent behavior across various passages, and availability in multiple cell types, which provides versatility for different experimental contexts. Additionally, ADRM1 Gene Knockout Cell Lines come with comprehensive validation reports, giving researchers confidence in their utility.
For researchers and clinicians working at the forefront of genetic research, these cell lines represent a remarkable opportunity to advance knowledge and develop new therapeutic interventions. Our company specializes in providing high-quality biological products, ensuring that scientists have access to the best resources for their groundbreaking work. Our commitment to quality and innovation is reflected in every product we offer, making us a trusted partner in scientific advancement.
Please note that all services are for research use only. Not intended for any clinical use.
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