Gene: ADNP
Official Full Name: activity dependent neuroprotector homeoboxprovided by HGNC
Gene Summary: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20403 | ADNP Knockout cell line (HeLa) | Human | ADNP | 1:3~1:6 | Negative | Online Inquiry |
KO20404 | ADNP Knockout cell line (HCT 116) | Human | ADNP | 1:2~1:4 | Negative | Online Inquiry |
KO20405 | ADNP Knockout cell line (HEK293) | Human | ADNP | 1:3~1:6 | Negative | Online Inquiry |
KO20406 | ADNP Knockout cell line (A549) | Human | ADNP | 1:3~1:4 | Negative | Online Inquiry |
ADNP Gene Knockout Cell Lines are advanced cellular models specifically designed to study the function and role of the activity-dependent neuroprotective protein (ADNP) gene in various biological processes. ADNP is known to be crucial for neuronal development and cognitive function, which makes these knockout models invaluable for dissecting the underlying mechanisms of neurodevelopmental disorders and neurodegenerative diseases.
These cell lines operate by utilizing CRISPR-Cas9 technology, which enables the precise editing of the ADNP gene, effectively disrupting its expression. This knockout allows researchers to observe the resultant phenotypic changes and alterations in cellular behavior, providing critical insights into ADNP's involvement in gene regulation, synaptic plasticity, and neuroprotection. By employing these models, scientists can efficiently explore the pathways affected by ADNP deficiency and assess potential therapeutic interventions.
The scientific importance of ADNP Gene Knockout Cell Lines lies in their application across numerous research fields, including neurobiology, genetics, and pharmacology. They serve as a powerful tool for investigating the pathogenesis of conditions such as autism spectrum disorders, Alzheimer’s disease, and other neurodegenerative disorders, facilitating the development of targeted therapies.
What sets our ADNP Gene Knockout Cell Lines apart from alternatives is their robust validation and high reproducibility in experimental outcomes. Unlike traditional animal models, our cell lines offer a more efficient and ethical approach to studying genetic influences, significantly reducing the variability commonly seen in vivo. Researchers and clinicians can leverage these models to generate data more rapidly and effectively translate findings into clinical applications.
Investing in ADNP Gene Knockout Cell Lines not only accelerates scientific discovery but also empowers researchers and clinicians to make impactful contributions to improving human health. Our company prides itself on a strong background in genetic research and cell line development, ensuring that our products meet the highest standards of quality and reliability for cutting-edge scientific investigation.
Please note that all services are for research use only. Not intended for any clinical use.
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