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ADGRL1 Knockout Cell Lines

Gene: ADGRL1

Official Full Name: adhesion G protein-coupled receptor L1provided by HGNC

Gene Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30220 ADGRL1 Knockout cell line (HeLa) Human ADGRL1 1:3~1:6 Negative Online Inquiry
KO30221 ADGRL1 Knockout cell line (HCT 116) Human ADGRL1 1:2~1:4 Negative Online Inquiry
KO30222 ADGRL1 Knockout cell line (HEK293) Human ADGRL1 1:3~1:6 Negative Online Inquiry
KO30223 ADGRL1 Knockout cell line (A549) Human ADGRL1 1:3~1:4 Negative Online Inquiry

Background

ADGRL1 Gene Knockout Cell Lines are genetically modified cell lines designed to facilitate the study of the adhesion G protein-coupled receptor (ADGRL1), also known as latrophilin-1. These cell lines have been created using CRISPR-Cas9 technology to effectively disrupt the ADGRL1 gene, allowing researchers to investigate its role in cellular processes such as cell adhesion, migration, and communication within the nervous system. This cell line serves as a valuable tool for elucidating the functional consequences of ADGRL1 loss, providing insights into signaling pathways that may influence neurodevelopment and potential pathologies.

The primary mechanism underlying the utility of ADGRL1 Gene Knockout Cell Lines lies in their ability to model alterations in cell behavior that mimic conditions found in various neurological disorders. By studying these knockout cell lines, scientists can assess changes in receptor signaling, evaluate the impacts on cellular morphology, and explore the roles of ADGRL1 in processes such as synaptogenesis and neurotransmitter release. This research is particularly crucial, as dysregulation of ADGRL1 has been implicated in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia.

Compared to traditional models, ADGRL1 Gene Knockout Cell Lines offer several advantages, including the specificity of gene targeting and the ability to replicate complex biological responses in a controlled environment. Unlike standard pharmacological inhibitors or global knockout models, these cell lines allow for the detailed study of ADGRL1 function in isolation, enabling the assessment of its specific contributions without confounding effects from other signaling pathways.

For researchers and clinicians, the value of ADGRL1 Gene Knockout Cell Lines cannot be overstated. This product provides a robust platform for developing targeted therapies and advancing our understanding of receptor functions in human health and disease. Furthermore, by investing in these specialized cell lines, users are positioned at the forefront of innovative research in neurobiology, benefitting from precise gene-editing technologies that drive scientific discovery.

With a strong background in genetic engineering and a commitment to advancing biomedical research, our company is proud to offer high-quality ADGRL1 Gene Knockout Cell Lines, backed by rigorous validation and extensive expertise in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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