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ADGRD1 Knockout Cell Lines

Gene: ADGRD1

Official Full Name: adhesion G protein-coupled receptor D1provided by HGNC

Gene Summary: The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19987 ADGRD1 Knockout cell line (HeLa) Human ADGRD1 1:3~1:6 Negative Online Inquiry

Background

ADGRD1 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the functional implications of the ADGRD1 gene, known for its role in a variety of physiological processes including cell signaling, adhesion, and migration. By utilizing CRISPR-Cas9 gene editing technology, these cell lines effectively deactivate the ADGRD1 gene, resulting in loss-of-function mutations that profoundly impact cellular behavior. This targeted modification allows researchers to dissect the precise biological pathways influenced by ADGRD1 and to observe the resulting phenotypic alterations in controlled environments.

The primary mechanism of action involves the disruption of gene expression, leading to the modulation of downstream signaling cascades associated with G-protein-coupled receptor functions. By knocking out ADGRD1, researchers can investigate its contributions to critical biological phenomena such as immune response, tissue differentiation, and pathogen-host interactions. These knockout cell lines offer significant scientific value in both basic research and clinical applications, facilitating studies in tumor biology, cardiovascular health, neurology, and more.

Compared to traditional knockdown methods, such as RNA interference, ADGRD1 Gene Knockout Cell Lines provide a more stable and enduring genetic modification, eliminating concerns related to off-target effects and transient expression levels. This enhances reproducibility and reliability in experimental results, which are crucial for robust data interpretation and further translational research.

Importantly, ADGRD1 Gene Knockout Cell Lines serve as valuable tools not only in academia but also in biopharmaceutical companies focusing on drug discovery and development. Given the growing relevance of G-protein-coupled receptors in therapeutic targets, these cell lines enable scientists to better explore novel compounds and their effects on cell behavior.

Our company specializes in creating advanced biological models that empower researchers to uncover intricate cellular mechanisms. With state-of-the-art technologies and a commitment to quality, we strive to support the scientific community in its pursuit of knowledge and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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