Gene: ADAP2
Official Full Name: ArfGAP with dual PH domains 2provided by HGNC
Gene Summary: The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19996 | ADAP2 Knockout cell line (HeLa) | Human | ADAP2 | 1:3~1:6 | Negative | Online Inquiry |
KO19997 | ADAP2 Knockout cell line (HCT 116) | Human | ADAP2 | 1:2~1:4 | Negative | Online Inquiry |
KO19998 | ADAP2 Knockout cell line (HEK293) | Human | ADAP2 | 1:3~1:6 | Negative | Online Inquiry |
KO19999 | ADAP2 Knockout cell line (A549) | Human | ADAP2 | 1:3~1:4 | Negative | Online Inquiry |
ADAP2 Gene Knockout Cell Lines are specialized cellular models in which the ADAP2 gene has been effectively disrupted using advanced gene-editing techniques such as CRISPR/Cas9. These cell lines enable researchers to study the function and regulation of the ADAP2 protein, which is known to play a crucial role in various signaling pathways influencing cell proliferation, differentiation, and immune responses. By eliminating the ADAP2 gene, these cell lines provide a unique platform to dissect the biological implications of ADAP2 depletion, thus enhancing our understanding of its role in physiological and pathological processes.
The primary mechanism behind the functionality of ADAP2 Gene Knockout Cell Lines is the complete loss of ADAP2 expression, which allows researchers to examine altered cellular behaviors and signaling pathways in the absence of this protein. This ability to create a controlled genetic environment enables precise analyses of downstream effects, facilitating insights into the molecular mechanisms governing immune responses, cell survival, and apoptosis, among other key biological processes.
In research and clinical applications, these knockout cell lines are invaluable tools for the development of targeted therapies and the investigation of diseases such as cancer and autoimmune disorders. By leveraging ADAP2-deficient models, researchers can uncover novel therapeutic targets and assess the efficacy of potential treatments, making significant contributions to translational medicine.
Distinct advantages of the ADAP2 Gene Knockout Cell Lines include the precision and reliability offered by the CRISPR/Cas9 editing technology, which ensures reproducible genetic modifications. Furthermore, unlike traditional knockout models, these cell lines provide a more accessible and versatile approach, allowing for high-throughput screening and rapid experimental workflows without the complications associated with whole-animal models.
For researchers, clinicians, and pharmaceutical developers, the ADAP2 Gene Knockout Cell Lines stand out as a critical resource, facilitating cutting-edge discoveries in basic research and drug development. Our company, specializing in gene editing technologies and cellular model development, is committed to delivering high-quality, reliable products that empower the scientific community to drive innovation in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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