Gene: ADAM22
Official Full Name: ADAM metallopeptidase domain 22provided by HGNC
Gene Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21938 | ADAM22 Knockout cell line (HeLa) | Human | ADAM22 | 1:3~1:6 | Negative | Online Inquiry |
KO21939 | ADAM22 Knockout cell line (HCT 116) | Human | ADAM22 | 1:2~1:4 | Negative | Online Inquiry |
KO21940 | ADAM22 Knockout cell line (HEK293) | Human | ADAM22 | 1:3~1:6 | Negative | Online Inquiry |
ADAM22 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the ADAM22 gene, known for its critical role in various physiological processes, including cell adhesion, signaling, and synaptic functions. By utilizing CRISPR-Cas9 technology, these knockout cell lines provide researchers with a powerful tool to assess the gene's contributions to neurobiology and pathology, offering insights into conditions such as neurodegenerative diseases and synaptic disorders.
The primary functions of ADAM22 involve the mediation of interactions between neural cells, impacting synaptic formation and function. By generating knockout models, scientists can observe the phenotypic consequences of ADAM22 absence, elucidating its role in cellular communication and signaling pathways. The applications of these cell lines span both research and clinical settings, making them indispensable for examining potential therapeutic targets and drug responses in neurological disorders.
Compared to other genetic models, the ADAM22 Gene Knockout Cell Lines offer unique advantages, including high specificity, reproducibility, and ease of use in experimental protocols. These lines also provide a platform for real-time observation of the effects of ADAM22 deletion on cellular behavior, enhancing the interpretability of research findings.
For researchers and clinicians alike, the ADAM22 Gene Knockout Cell Lines represent a valuable resource, facilitating advanced studies that can lead to significant discoveries in neuroscience. By understanding the intricate role of ADAM22, researchers can contribute to the development of innovative therapies aimed at addressing neurological impairments.
With a commitment to advancing scientific research, our company specializes in producing high-quality biological reagents and cell models that empower researchers to uncover critical insights in their fields. Our expertise and dedication to excellence ensure that we deliver products that meet the evolving demands of biomedical science.
Please note that all services are for research use only. Not intended for any clinical use.
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