Gene: ADAM11
Official Full Name: ADAM metallopeptidase domain 11provided by HGNC
Gene Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36692 | ADAM11 Knockout cell line (HCT 116) | Human | ADAM11 | 1:2~1:4 | Negative | Online Inquiry |
KO36693 | ADAM11 Knockout cell line (HEK293) | Human | ADAM11 | 1:3~1:6 | Negative | Online Inquiry |
KO36694 | ADAM11 Knockout cell line (A549) | Human | ADAM11 | 1:3~1:4 | Negative | Online Inquiry |
ADAM11 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the ADAM11 gene, which encodes a member of the A Disintegrin And Metalloproteinase (ADAM) family. The ADAM proteins play crucial roles in cell adhesion, migration, and signaling processes, making their regulation critical for various physiological and pathological conditions. The ADAM11 protein has been implicated in processes such as neurogenesis and inflammation, thereby making its study essential for understanding numerous diseases, including neurological disorders and cancers.
These knockout cell lines serve as essential tools to elucidate the biological functions and pathways involving ADAM11. By removing this gene, researchers can investigate the resultant cellular behavior and signaling alterations, which can provide insights into the molecular mechanisms underlying disease progression or therapeutic responses. The unique design of these cell lines allows for controlled experimental environments, enabling researchers to dissect the effects of ADAM11 absence on cellular dynamics and interactions.
The scientific importance of ADAM11 Gene Knockout Cell Lines extends to both basic research and clinical applications. They are invaluable for developing targeted therapies, as understanding the implications of ADAM11 loss could lead to novel interventions in cancers or neurodegenerative diseases. Furthermore, as researchers increasingly pursue precision medicine approaches, these knockout models could help tailor treatment strategies based on individual genetic profiles.
Unlike conventional cell lines, which may express confounding factors, the ADAM11 knockout models offer greater specificity and reduced variability in experiments focused on ADAM11-related pathways. This feature enhances experimental reproducibility and reliability, making the findings more robust.
For researchers and clinicians, ADAM11 Gene Knockout Cell Lines provide a distinct advantage, as they contribute to a refined understanding of ADAM-related processes within human health and disease. By incorporating these models into your investigations, you can increase your potential for groundbreaking discoveries that may lead to the development of novel therapeutic strategies.
Our company specializes in providing high-quality biological products tailored for advanced research, and we are committed to supporting the scientific community with innovative solutions like the ADAM11 Gene Knockout Cell Lines. Our expertise and dedication to quality assurance ensure that you can rely on our products for your most critical research applications.
Please note that all services are for research use only. Not intended for any clinical use.
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