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ACSS2 Knockout Cell Lines

Gene: ACSS2

Official Full Name: acyl-CoA synthetase short chain family member 2provided by HGNC

Gene Summary: This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20027 ACSS2 Knockout cell line (HeLa) Human ACSS2 1:3~1:6 Negative Online Inquiry
KO20028 ACSS2 Knockout cell line (HCT 116) Human ACSS2 1:2~1:4 Negative Online Inquiry
KO20029 ACSS2 Knockout cell line (HEK293) Human ACSS2 1:3~1:6 Negative Online Inquiry
KO20030 ACSS2 Knockout cell line (A549) Human ACSS2 1:3~1:4 Negative Online Inquiry

Background

ACSS2 Gene Knockout Cell Lines are a sophisticated and invaluable tool for researchers studying metabolic pathways and cellular processes influenced by the acyl-CoA synthetase short-chain family member 2 (ACSS2) gene. These knockout cell lines are engineered to eliminate the expression of ACSS2, enabling the exploration of its role in various physiological and pathological contexts, particularly in the regulation of fatty acid metabolism and energy homeostasis.

The key mechanism of these cell lines lies in their ability to mimic disease states by providing a controlled environment where researchers can observe the effects of ACSS2 deficiency. This allows for in-depth investigations into cell signaling pathways, metabolic disorders, and the effects of potential therapeutic interventions. By analyzing phenotypic changes, researchers can elucidate the gene’s contributions to energy metabolism and its implications in cancer, obesity, and metabolic syndromes.

The scientific importance of ACSS2 Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, these cell lines facilitate the identification of novel drug targets and biomarkers, enhancing our understanding of metabolic diseases. Clinically, the insights gained can lead to the development of innovative treatment strategies aimed at manipulating the metabolic pathways associated with ACSS2.

When compared to other available models, ACSS2 Gene Knockout Cell Lines offer specific advantages, including more precise genetic control and reproducibility of experimental results. Their utilization eliminates confounding variables that often arise from incomplete knockdown methods, thus ensuring reliable data that can accelerate translational research.

This product is an essential asset for researchers and clinicians seeking to advance the understanding of metabolic regulation at the cellular level. By utilizing ACSS2 Gene Knockout Cell Lines, users are equipped with a powerful tool that can significantly impact research outcomes and potential clinical applications.

Our company is dedicated to providing high-quality biological products, and our expertise in gene editing technologies ensures that researchers have access to cutting-edge tools that meet their needs in the ever-evolving landscape of scientific exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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