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ACOX1 Knockout Cell Lines

Gene: ACOX1

Official Full Name: acyl-CoA oxidase 1provided by HGNC

Gene Summary: The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00329 ACOX1 gRNA1-gRNA2 KO plasmid ACOX1 $850
GP00336 ACOX1 gRNA3-gRNA4 KO plasmid ACOX1 $850
KO00676 ACOX1 Knockout cell line(Hep G2) Human ACOX1 1:2~1:4 Negative Online Inquiry
KO07562 ACOX1 Knockout cell line (HeLa) Human ACOX1 1:3~1:6 Negative Online Inquiry
KO07563 ACOX1 Knockout cell line (HCT 116) Human ACOX1 1:2~1:4 Negative Online Inquiry
KO07564 ACOX1 Knockout cell line (HEK293) Human ACOX1 1:3~1:6 Negative Online Inquiry
KO07565 ACOX1 Knockout cell line (A549) Human ACOX1 1:3~1:4 Negative Online Inquiry

Background

ACOX1 Gene Knockout Cell Lines are specifically engineered cellular models designed to study the impact of the acyl-CoA oxidase 1 (ACOX1) gene's absence on metabolic pathways and cellular function. These knockout cell lines provide a robust tool for researchers interested in the roles of fatty acid metabolism, peroxisomal function, and implications in various metabolic disorders.

The ACOX1 gene encodes an enzyme crucial for the initial step in the β-oxidation of very long-chain fatty acids in peroxisomes, leading to the formation of hydrogen peroxide. By introducing targeted deletions in the ACOX1 gene, these cell lines facilitate the exploration of metabolic shifts and compensate mechanisms that may arise from altered fatty acid processing. This enables researchers to gain insights into pathways associated with metabolic syndrome, obesity, and related disorders.

From a scientific perspective, ACOX1 Gene Knockout Cell Lines have vast applications in both basic and applied research. They are invaluable for studying the effects of compromised peroxisomal function and metabolic dysregulation and serve as platforms for drug discovery aimed at enhancing fatty acid oxidation or targeting metabolic diseases. The ability to produce these knockout lines with precision ensures replicable and relevant results, enhancing experimental robustness.

What sets ACOX1 Gene Knockout Cell Lines apart from other cellular models is the specificity and efficiency with which they provide insights into ACOX1-associated pathways without interference from other genes. These models also allow for a controlled environment to examine compensatory pathways in lipid metabolism, offering researchers a focused view of cellular responses under specific genetic perturbations.

For researchers and clinicians, leveraging ACOX1 Gene Knockout Cell Lines can significantly boost productivity by providing a reliable system for studying metabolic diseases and developing therapeutic strategies. This product is essential for those focused on advancing our understanding of lipid metabolism and its broader implications in human health.

Our company is dedicated to delivering cutting-edge biological tools and reagents that empower the scientific community. With expertise in genetic engineering and a commitment to quality, we provide products that enhance research capabilities and drive innovation in metabolic health studies.

Please note that all services are for research use only. Not intended for any clinical use.

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