Gene: ACIN1
Official Full Name: apoptotic chromatin condensation inducer 1provided by HGNC
Gene Summary: Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30059 | ACIN1 Knockout cell line (HeLa) | Human | ACIN1 | 1:3~1:6 | Negative | Online Inquiry |
KO30060 | ACIN1 Knockout cell line (HCT 116) | Human | ACIN1 | 1:2~1:4 | Negative | Online Inquiry |
KO30061 | ACIN1 Knockout cell line (HEK293) | Human | ACIN1 | 1:3~1:6 | Negative | Online Inquiry |
ACIN1 Gene Knockout Cell Lines are advanced biological tools specifically designed to facilitate the study of the ACIN1 gene's role in cellular processes. The ACIN1 gene is known for its involvement in RNA metabolism and cellular signal transduction, impacting various physiological functions. By creating a knockout of this gene, researchers can observe and analyze the consequent phenotypic changes and intracellular mechanisms, allowing for a deeper understanding of its function and involvement in diseases such as cancer and neurodegenerative disorders.
These specialized cell lines employ the CRISPR-Cas9 gene-editing technology to precisely eliminate the ACIN1 gene, thereby providing researchers with a valuable model system to elucidate the gene’s contributions to biological pathways. The knockout mechanism leads to loss-of-function studies where researchers can assess changes in gene expression, protein interactions, and the overall impact on cellular behavior under various conditions, enriching our understanding of the gene’s physiological relevance.
The scientific importance of ACIN1 Gene Knockout Cell Lines extends to both basic research and clinical applications. They serve as critical models for drug discovery, toxicology testing, and the development of novel therapeutic strategies targeting specific pathways influenced by the ACIN1 gene. Furthermore, these cell lines enable researchers to validate findings related to gene-function interactions and to explore the effects of ACIN1 modulation in relevant cellular contexts.
Compared to traditional knockout models, our ACIN1 Gene Knockout Cell Lines provide a cost-effective, time-efficient, and reproducible alternative that enhances experimental rigor. They are specifically characterized for high stability and ease of culture, which allows for seamless integration into existing laboratory workflows. This leads to increased throughput and more robust data.
Our product is invaluable to researchers and clinicians aiming to explore gene function in a controlled environment, providing the clarity needed to direct future studies or therapeutic approaches. By leveraging decades of expertise in molecular biology and cutting-edge gene-editing technology, our company ensures that you have access to the most reliable and innovative tools for advanced genetic studies.
Please note that all services are for research use only. Not intended for any clinical use.
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