Gene: ACACB
Official Full Name: acetyl-CoA carboxylase betaprovided by HGNC
Gene Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. [provided by RefSeq, Oct 2022]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07436 | ACACB Knockout cell line (HeLa) | Human | ACACB | 1:3~1:6 | Negative | Online Inquiry |
KO07437 | ACACB Knockout cell line (HCT 116) | Human | ACACB | 1:2~1:4 | Negative | Online Inquiry |
KO07438 | ACACB Knockout cell line (HEK293) | Human | ACACB | 1:3~1:6 | Negative | Online Inquiry |
KO07439 | ACACB Knockout cell line (A549) | Human | ACACB | 1:3~1:4 | Negative | Online Inquiry |
ACACB Gene Knockout Cell Lines are specialized cellular models created to facilitate the study of the Acetyl-CoA Carboxylase Beta (ACACB) gene, which plays a pivotal role in fatty acid metabolism and energy homeostasis. These cell lines are engineered to harbor specific deletions in the ACACB gene, thereby allowing researchers to assess the functional consequences of abolishing ACACB expression. By removing this gene, scientists can investigate alterations in metabolic pathways and understand the contributions of ACACB to various physiological and pathological conditions.
The fundamental mechanism of action relies on the core pathways regulated by ACACB in lipid biosynthesis and insulin signaling. With the knockout of the ACACB gene, researchers observe changes in both anabolic and catabolic processes, particularly in the context of metabolic diseases such as obesity and type 2 diabetes. This makes ACACB Gene Knockout Cell Lines invaluable tools not only for fundamental biological research but also for clinical implications, such as the development of targeted therapies.
Compared to standard cell lines, ACACB Gene Knockout Cell Lines offer unique advantages. They provide a specific model for studying the absence of ACACB function, which gives deeper insights into metabolic regulation that would otherwise be obscured in wild-type models. Furthermore, they contribute to the validation of therapeutic targets by providing a clear baseline against which the effects of potential drugs can be measured.
Researchers and clinicians seeking to unravel the complexities of metabolic disorders will find these knockout cell lines as essential components in their toolkit. Their ability to deliver reproducible results enhances the reliability of research findings, making them indispensable for investigations into disease mechanisms and treatment approaches.
Our company's expertise in genetic engineering and cell line development ensures that the ACACB Gene Knockout Cell Lines are of the highest quality, supporting the scientific community with cutting-edge tools essential for pioneering research.
Please note that all services are for research use only. Not intended for any clinical use.
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