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ABAT Knockout Cell Lines

Gene: ABAT

Official Full Name: 4-aminobutyrate aminotransferaseprovided by HGNC

Gene Summary: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05074 ABAT Knockout cell line (HCT 116) Human ABAT 1:2~1:4 Negative Online Inquiry
KO05075 ABAT Knockout cell line (HEK293) Human ABAT 1:3~1:6 Negative Online Inquiry

Background

ABAT Gene Knockout Cell Lines represent a cutting-edge resource in the field of molecular biology, specifically designed to study the biochemical pathways and regulatory mechanisms involving the abscisic acid (ABA) metabolism. These cell lines have been genetically engineered to disrupt the expression of the ABAT gene, which encodes an enzyme involved in the catabolism of ABA. By elucidating the impact of this knockout on cellular functions, researchers can gain profound insights into stress responses, metabolic regulation, and plant development.

The key mechanism by which ABAT Gene Knockout Cell Lines function involves the elimination of the enzyme responsible for the conversion of ABA to its inactive forms, thereby providing an ideal model for studying the implications of ABA accumulation in various physiological processes. By using these cell lines, scientists can explore how altered ABA levels affect cellular signaling pathways, transcriptional regulation, and stress adaptability, ultimately advancing our understanding of plant physiology and its applications in agriculture.

Scientifically, these knockout cell lines are invaluable in both research and clinical settings. They serve as essential tools for investigating the roles of ABA in controlling plant responses to environmental stressors, with potential implications in crop engineering for enhanced resilience. Moreover, insights garnered from such models may parallel human health studies concerning stress-related pathways in various diseases.

What sets ABAT Gene Knockout Cell Lines apart from conventional cell culture systems is the precision and specificity of the genetic modification, which allows for a focused exploration of ABA-related processes. Compared to alternative models, these cell lines provide a clear advantage in replicating endogenous ABA signaling systems, ensuring more reliable and reproducible data. This specificity minimizes off-target effects often seen in less tailored models, providing researchers with confidence in their experimental outcomes.

In summary, ABAT Gene Knockout Cell Lines are an essential asset for researchers and clinicians alike, enabling breakthroughs in the understanding of ABA's role in significant biological functions. With a robust commitment to excellence and innovation, our company offers these advanced cellular models as part of a comprehensive portfolio designed to support cutting-edge research in plant biology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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