Introduction
One of the key components of synthetic biology is the creation of novel strains with unique properties that can be used for various applications such as biotechnology, medicine, and agriculture. Strain hybridization is an essential technique in synthetic biology that involves the combination of genetic material from different strains to create a new hybrid strain with desired traits.
CD Biosynsis is a leading biotechnology company that specializes in strain hybridization for various applications, which offers a wide range of services for strain hybridization, including strain selection, hybridization techniques, strain characterization, and scale-up and optimization.
Figure 1: The principles of in situ hybridization chain reaction. (Veselinyová, D.; Mašlanková, J., et al. 2021)
Our Services for strain hybridization
Strain Selection
Our team of experts uses a systematic approach for strain selection to identify the most suitable strains for hybridization based on the desired properties and applications. We have extensive experience in selecting strains for various applications, including industrial biotechnology, agriculture, and medicine.
Our services for strain selection include:
Strain isolation and identification
Screening of strains for desired properties such as high yield, specificity, and selectivity
Selection of the most appropriate strains for hybridization based on the desired properties and applications
Consultation services to help clients choose the best strains for their specific needs.
Hybridization Techniques
We use various hybridization techniques to combine genetic material from different strains, including traditional techniques such as conjugation, transformation, and transduction, as well as modern techniques such as CRISPR-Cas9-mediated genome editing.
Our services for hybridization techniques include:
Conjugation, transformation, and transduction techniques for traditional hybridization
CRISPR-Cas9-mediated genome editing for precise genome modifications
Recombination and gene editing techniques for targeted genetic modifications
Consultation services to help clients choose the most appropriate hybridization techniques for their specific needs.
Strain Characterization
Our team performs extensive characterization of the hybrid strains to ensure that they have the desired properties and meet quality standards. We use various techniques such as DNA sequencing, PCR, and phenotypic analysis to characterize the hybrid strains.
Our services for strain characterization include:
DNA sequencing and analysis to identify genetic modifications and confirm strain identity
PCR analysis to detect specific genes or markers
Phenotypic analysis to assess the properties and performance of the hybrid strains
Consultation services to help clients choose the most appropriate characterization techniques for their specific needs.
Scale-Up and Optimization
We provide scale-up and optimization services to ensure that the hybrid strains can be produced efficiently and at large scale. We use various techniques such as fermentation, bioreactors, and downstream processing to optimize the production of the hybrid strains.
Our services for scale-up and optimization include:
Fermentation and bioreactor optimization for efficient production of the hybrid strains
Downstream processing for purification and recovery of the desired products
Process optimization and scale-up to ensure efficient and cost-effective production
Consultation services to help clients choose the most appropriate scale-up and optimization strategies for their specific needs.
Our Advantages
- Comprehensive strain selection process
Our team of experts uses a systematic approach to identify the most suitable strains for hybridization based on the desired properties and applications.
- Advanced hybridization techniques
We use a variety of hybridization techniques, including traditional methods such as conjugation, transformation, and transduction, as well as modern techniques such as CRISPR-Cas9-mediated genome editing.
- Extensive strain characterization
We use various techniques such as DNA sequencing, PCR, and phenotypic analysis to characterize the hybrid strains.
- Documentation and quality control
We ensure that the documentation quality and procedures of strain origin are assessed and approved by a qualified quality assurance service.
- Customization
We offer customized services that are tailored to the specific needs of our clients.
CD Biosynsis is a leading biotechnology company that specializes in strain hybridization for various applications. Our team of experts has extensive experience in strain hybridization for various applications and uses the latest technologies and techniques to ensure the highest standards of quality and safety. Contact us today to learn more about our strain hybridization and how we can help optimize your microbial strains for maximum performance.
References
- Veselinyová, D.; Mašlanková, J., et al. Selected In Situ Hybridization Methods: Principles and Application. Molecules 2021, 26, 3874.
- Krogerus Kristoffer, Magalhães Frederico, et al. New lager yeast strains generated by interspecific hybridization [J]. Journal of Industrial Microbiology and Biotechnology, 2015, 42(5): 769-778.
- Luria S.E., Burrous J.W. Hybridization between Escherichia coli and Shigella. Journal of bacteriology, 1957, 74(4): 461-476.
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