ATRX Knockout cell line (MFE-280)

Name: ATRX Knockout cell line (MFE-280)
Brand: CD Biosynsis
SKU: KOA409676
Availability: InStock

Catalog Number: KOA409676

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Specifications

Product Information
Product Name	ATRX Knockout cell line (MFE-280)
specification	1*10^6
Storage and transportation	Shipped on dry ice; Store in liquid nitrogen
Cell morphology	Epithelial-like, adherent
Passage ratio	1：2-1：3
Gene	ATRX
Gene ID	546
Build method	Electroporation/Lentivirus
Mycoplasma testing	negative
Cultivation system	88%MEM+10%FBS+1%NEAA+1%1%Sodium Pyruvate
Parental Cell Line	MFE-280
Quality Control	Genotype: ATRX Knockout cell line (MFE-280)>95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	ATRX chromatin remodelerprovided by HGNC
Also known as	JMS; XH2; XNP; MRX52; RAD54; RAD54L; ZNF-HX
Gene Description	The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Expression	Ubiquitous expression in brain (RPKM 12.1), endometrium (RPKM 9.2) and 25 other tissues See more

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