Gene: P2RX1
Official Full Name: purinergic receptor P2X 1provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08100 | P2RX1 Knockout cell line (HeLa) | Human | P2RX1 | 1:3~1:6 | Negative | Online Inquiry |
P2RX1 Gene Knockout Cell Lines represent a powerful tool in molecular biology, specifically designed to investigate the physiological and pathological roles of the purinergic receptor P2X1. These genetically engineered cell lines feature a complete knockout of the P2RX1 gene, which encodes the P2X1 receptor, a key player in ATP-mediated signaling pathways that influence various cellular processes such as neurotransmission, immune response, and cell proliferation. Researchers utilize these knockout cell lines to elucidate the receptor's function by comparing the phenotypic and behavioral properties of the knockout cells with their wild-type counterparts.
The mechanism of action in P2RX1 knockout cell lines is straightforward; by disrupting the expression of P2X1, these cell lines enable the study of downstream signaling cascades and physiological outcomes that are typically mediated through ATP binding. This offers invaluable insights into the role of purinergic signaling in diseases such as hypertension, cardiovascular disease, and chronic inflammatory conditions. Such functional characterization is critical in preclinical research and drug development, where purinergic receptors represent promising therapeutic targets.
One of the standout features of our P2RX1 Gene Knockout Cell Lines is their specificity and reliability. Unlike other approaches that may involve transient knockdown, our stable knockout lines assure consistent and reproducible results, which are essential for rigorous scientific inquiry. Furthermore, the ease of use in standard laboratory settings coupled with detailed protocols provided by our team enhances user experience and accelerates experimentation timelines.
By integrating these knockout cell lines into their research, scientists and clinicians can explore complex disease mechanisms, contributing to innovative therapeutic strategies. Our commitment to quality and scientific excellence ensures that our customers receive a product that stands at the forefront of biological research advancements. With years of expertise in developing cutting-edge biological tools, we are dedicated to supporting the scientific community in their pursuit of groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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