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EGF Knockout Cell Lines

Gene: EGF

Official Full Name: epidermal growth factorprovided by HGNC

Gene Summary: This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11314 EGF Knockout cell line (A549) Human EGF 1:3~1:4 Negative Online Inquiry

Background

EGF Gene Knockout Cell Lines are genetically modified cell lines specifically designed to disrupt the expression of the Epidermal Growth Factor (EGF) gene. This innovative product allows researchers to study the biological functions and signaling pathways associated with EGF without the interference of this essential growth factor. The knockout mechanism typically involves techniques such as CRISPR-Cas9 or RNA interference, effectively silencing the target gene and enabling the observation of phenotypic changes in cellular behavior.

The primary function of EGF Gene Knockout Cell Lines is to facilitate research in cellular growth, differentiation, and responses to various stimuli, particularly in the context of cancer and tissue regeneration. By utilizing these cell lines, researchers can investigate how the absence of EGF influences cell proliferation, survival, and migration, thus elucidating its crucial role in both physiological and pathological processes.

In scientific and clinical research, the EGF gene is a critical target due to its involvement in oncogenesis and various skin and tissue-related disorders. The implications of studying its knockout model extend to developing novel therapeutic strategies, including drug discovery and personalized medicine targeting EGF signaling pathways.

Compared to traditional cell line models, EGF Gene Knockout Cell Lines provide unparalleled specificity and control, allowing researchers to obtain more reliable data. Their precise gene editing significantly reduces variability often seen in experimental outcomes, ensuring higher reproducibility in research findings.

The value of EGF Gene Knockout Cell Lines to researchers and clinicians lies in their potential to unlock new insights into EGF's role in disease mechanisms and treatment responses. By providing a robust platform for hypothesis testing and experimental validation, these cell lines can accelerate discoveries that translate into meaningful therapeutic advances.

Our company specializes in innovative biological products tailored to meet the evolving needs of research and clinical applications. With a commitment to quality and scientific accuracy, we ensure that our offerings, such as the EGF Gene Knockout Cell Lines, empower the scientific community in their quest for knowledge and therapeutic breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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