Gene: ZNF277
Official Full Name: zinc finger protein 277provided by HGNC
Gene Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and metal ion binding activity. Predicted to act upstream of or within cellular response to hydrogen peroxide and regulation of cellular senescence. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31116 | ZNF277 Knockout cell line (HeLa) | Human | ZNF277 | 1:3~1:6 | Negative | Online Inquiry |
KO31117 | ZNF277 Knockout cell line (HCT 116) | Human | ZNF277 | 1:2~1:4 | Negative | Online Inquiry |
KO31118 | ZNF277 Knockout cell line (HEK293) | Human | ZNF277 | 1:3~1:6 | Negative | Online Inquiry |
KO31119 | ZNF277 Knockout cell line (A549) | Human | ZNF277 | 1:3~1:4 | Negative | Online Inquiry |
ZNF277 Gene Knockout Cell Lines are genetically modified cellular models designed to facilitate the study of gene function and the biological implications of ZNF277, a member of the zinc finger protein family that plays pivotal roles in various regulatory processes within cells. These knockout cell lines have been precisely engineered through CRISPR-Cas9 technology to disrupt the ZNF277 gene, enabling researchers to investigate the resulting phenotypic changes and elucidate the gene's role in cellular mechanisms such as proliferation, differentiation, and stress responses.
The core function of ZNF277 involves its role in transcriptional regulation and gene expression modulation, contributing to the maintenance of cellular homeostasis. By utilizing these knockout cell lines, researchers can dissect the molecular pathways influenced by ZNF277, providing insights into its involvement in diseases, particularly in cancer biology and other disorders. Experimental applications include high-throughput screening, validation of therapeutic targets, and the exploration of gene-environment interactions within cellular systems.
One of the significant advantages of the ZNF277 Gene Knockout Cell Lines over traditional gene silencing methods, such as siRNA or shRNA, is the permanent and heritable gene disruption, enabling long-term studies without the risk of gene reactivation. Furthermore, these cell lines are rigorously validated for specificity and reproducibility, ensuring that results are reliable and consistent across different experimental replicates.
This product holds immense value for researchers looking to deepen their understanding of gene function and its clinical implications. The insights gained from studies using ZNF277 knockout cell lines could lead to identifying novel biomarkers and therapeutic targets, enhancing the development of personalized medicine approaches.
Our company specializes in providing high-quality, precision-engineered biological products that bolster research capabilities in genetic studies. With our commitment to innovation and scientific accuracy, we equip researchers and clinicians with the tools necessary to advance their understanding of complex biological processes.
Please note that all services are for research use only. Not intended for any clinical use.
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