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ZMIZ2 Knockout Cell Lines

Gene: ZMIZ2

Official Full Name: zinc finger MIZ-type containing 2provided by HGNC

Gene Summary: ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06835 ZMIZ2 Knockout cell line (HeLa) Human ZMIZ2 1:3~1:6 Negative Online Inquiry
KO06836 ZMIZ2 Knockout cell line (HCT 116) Human ZMIZ2 1:2~1:4 Negative Online Inquiry
KO06837 ZMIZ2 Knockout cell line (HEK293) Human ZMIZ2 1:3~1:6 Negative Online Inquiry
KO06838 ZMIZ2 Knockout cell line (A549) Human ZMIZ2 1:3~1:4 Negative Online Inquiry

Background

ZMIZ2 Gene Knockout Cell Lines are precision-engineered cellular models that facilitate the exploration of gene function, regulation, and associated phenotypes by disrupting the ZMIZ2 gene. Utilizing CRISPR-Cas9 technology, these cell lines provide a powerful tool for researchers to investigate the implications of ZMIZ2 loss on various biological pathways and cellular processes. The knockout mechanism effectively introduces targeted mutations, resulting in a complete loss of ZMIZ2 protein expression, thereby enabling the study of downstream effects that contribute to understanding disease pathogenesis or drug responses.

The scientific importance of ZMIZ2 Gene Knockout Cell Lines is underscored by their applications in both basic and translational research settings. ZMIZ2 is implicated in significant biological processes, including transcriptional regulation, and its dysregulation is associated with several diseases, including cancer and autoimmune disorders. By employing these cell lines, researchers can dissect the role of ZMIZ2 in cellular signaling, gene expression, and metabolic pathways, paving the way for novel therapeutic strategies and biomarker discovery.

A unique selling point of our ZMIZ2 Gene Knockout Cell Lines is their reliability and reproducibility compared to traditional gene knockdown approaches, such as RNA interference. The permanent and specific knockout of the ZMIZ2 gene allows for more straightforward interpretation of experimental results and reduces potential variability in outcomes. Furthermore, these cell lines are rigorously validated for authenticity and functionality, ensuring that researchers can trust the reliability of their findings.

For researchers and clinicians seeking to deepen their understanding of the ZMIZ2 gene's role in health and disease, these knockout cell lines offer an invaluable resource. They empower scientists to advance their research toward impactful discoveries, ultimately contributing to the development of innovative interventions in clinical practice.

Our company specializes in the production of high-quality biological products, including customized knockout cell lines and other gene editing tools, backed by extensive expertise in molecular biology and cell culture. With a commitment to supporting the research community, we aim to provide exceptional products that drive scientific advancement and improve patient outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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