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TRIML2 Knockout Cell Lines

Gene: TRIML2

Official Full Name: tripartite motif family like 2provided by HGNC

Gene Summary: This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34027 TRIML2 Knockout cell line (HCT 116) Human TRIML2 1:2~1:4 Negative Online Inquiry
KO34028 TRIML2 Knockout cell line (A549) Human TRIML2 1:3~1:4 Negative Online Inquiry

Background

TRIML2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the TRIML2 gene, a critical regulator involved in various cellular processes, including immune response and apoptosis. By eliminating the TRIML2 gene, these cell lines provide researchers with a powerful tool to elucidate the role of this gene in health and disease, particularly in the context of cancer, autoimmune disorders, and infectious diseases.

The primary mechanism of action involves the disruption of TRIML2's coding region through targeted gene-editing techniques such as CRISPR/Cas9. This knockout strategy enables researchers to investigate the phenotypic and functional consequences of TRIML2 deficiency, facilitating a deeper understanding of its biological roles, including its influence on protein ubiquitination and signaling pathways.

The scientific importance of TRIML2 Gene Knockout Cell Lines lies in their wide-ranging applications, particularly in the realms of molecular biology, pharmacology, and therapeutic development. In clinical settings, these models can be instrumental for drug screening and development processes, allowing clinicians and researchers to observe the effects of novel compounds on cells lacking TRIML2, thereby paving the way for targeted therapies.

One notable advantage of TRIML2 Gene Knockout Cell Lines compared to traditional cell models is their precise genetic modification, which enables reproducibility and a high level of specificity in experimental results. This minimizes the variability often encountered in standard cell lines, offering superior reliability for longitudinal studies.

For researchers and clinicians, the value of these cell lines extends beyond experimental rigor; they represent a strategic asset for investigating disease mechanisms, identifying therapeutic targets, and accelerating the translational potential of research findings.

Our company specializes in providing high-quality biological products tailored for advanced research and clinical applications. With a commitment to scientific excellence and rigorous quality control, we ensure that our products, including the TRIML2 Gene Knockout Cell Lines, empower your investigations and support groundbreaking discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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