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TNFSF4 Knockout Cell Lines

Gene: TNFSF4

Official Full Name: TNF superfamily member 4provided by HGNC

Gene Summary: This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05836 TNFSF4 Knockout cell line (HCT 116) Human TNFSF4 1:2~1:4 Negative Online Inquiry

Background

TNFSF4 Gene Knockout Cell Lines are specialized cell cultures that have been genetically modified to disrupt the TNFSF4 gene, also known as OX40L. This product serves as a valuable tool for researchers studying immune response mechanisms and T-cell activation. The TNFSF4 gene encodes a ligand that plays a crucial role in the interaction between T-cells and antigen-presenting cells, influencing the proliferation and survival of T-cells during immune responses. By utilizing these knockout cell lines, researchers can strategically investigate the specific functions and pathways associated with TNFSF4, unveiling new insights into immune regulation.

In functional assays, these cell lines offer a unique opportunity to explore the contribution of TNFSF4 in various immunological contexts, such as autoimmune diseases, cancer immunotherapy, and infectious disease response. The disruption of TNFSF4 helps researchers decipher the ligand-receptor interactions that govern T-cell polarization and memory formation, thus opening avenues for therapeutic interventions that aim to modulate immune responses.

One of the key advantages of using TNFSF4 Gene Knockout Cell Lines over traditional wild-type models is the precision with which these lines allow for functional assays that can directly correlate gene disruption with changes in T-cell behavior. This specificity is essential for minimizing misleading data often associated with heterogeneous cell populations. Furthermore, these knockout cell lines provide a consistent, reproducible framework that significantly expedites research timelines.

For researchers and clinicians aiming to enhance their understanding of T-cell biology or looking to develop targeted immunotherapeutics, TNFSF4 Gene Knockout Cell Lines offer an indispensable resource. Their distinctive capability to elucidate the role of OX40L in immune mechanisms positions them as a critical asset in both basic and applied biomedical research.

Furthermore, our company specializes in creating high-quality, genetically modified cell lines with superior validation and characterization. We are committed to providing researchers with innovative tools that propel their studies forward, ensuring that our products meet the evolving demands of scientific research in immunology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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