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TMTC4 Knockout Cell Lines

Gene: TMTC4

Official Full Name: transmembrane O-mannosyltransferase targeting cadherins 4provided by HGNC

Gene Summary: This gene encodes a transmembrane protein that belongs to family of proteins containing an N-terminal transmembrane domain and a C-terminal tetratricopeptide repeat (TPR) domain. TPR domains mediate protein-protein interactions in various cellular processes, such as synaptic vesicle fusion, protein folding, and protein translocation. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24514 TMTC4 Knockout cell line (HeLa) Human TMTC4 1:3~1:6 Negative Online Inquiry
KO24515 TMTC4 Knockout cell line (HCT 116) Human TMTC4 1:2~1:4 Negative Online Inquiry
KO24516 TMTC4 Knockout cell line (HEK293) Human TMTC4 1:3~1:6 Negative Online Inquiry
KO24517 TMTC4 Knockout cell line (A549) Human TMTC4 1:3~1:4 Negative Online Inquiry

Background

TMTC4 Gene Knockout Cell Lines are specialized cultured cells that have had the TMTC4 gene functionally disrupted, creating a model system for studying the biological role of this gene. These knockout cell lines are engineered using advanced CRISPR-Cas9 technology, which introduces targeted mutations into the TMTC4 locus, thereby leading to the loss of gene function. Researchers can utilize these cell lines to investigate the implications of TMTC4 in cellular processes such as endoplasmic reticulum (ER) stress response, protein folding, and potential roles in various diseases.

The primary function of the TMTC4 knockout cell lines lies in their ability to facilitate detailed functional analysis of the TMTC4 gene. By observing phenotypic changes and alterations in cellular pathways, scientists can elucidate the contributions of TMTC4 to disease mechanisms and therapeutic responses. This is crucial in research areas such as cancer biology, neurodegenerative diseases, and metabolic disorders, where aberrations in protein handling and stress response are often involved.

These cell lines offer significant advantages over traditional methods, such as transient knockdown models that provide only temporary insights. TMTC4 knockout cell lines yield more stable and reproducible data, allowing for long-term experimental observations and the development of robust conclusions. Moreover, they can be used in high-throughput screening assays, dramatically increasing the efficiency of drug discovery processes targeting TMTC4-related pathways.

Researchers and clinicians will find value in the TMTC4 Gene Knockout Cell Lines for their ability to accelerate investigations into therapeutic targets and biomarker discovery. These tools can also aid in validating drug efficacy and safety by providing a reliable in vitro platform.

Leveraging years of expertise in gene editing technology and cellular models, our company specializes in providing high-quality, validated biological products, ensuring researchers have access to the best tools necessary for advancing their studies. Utilizing TMTC4 knockout cell lines can greatly enhance the scope and impact of biomedical research, facilitating the exploration of novel therapeutic strategies.

Please note that all services are for research use only. Not intended for any clinical use.

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