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TMEM231 Knockout Cell Lines

Gene: TMEM231

Official Full Name: transmembrane protein 231provided by HGNC

Gene Summary: This gene encodes a transmembrane protein, which is a component of the B9 complex involved in the formation of the diffusion barrier between the cilia and plasma membrane. Mutations in this gene cause Joubert syndrome (JBTS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13197 TMEM231 Knockout cell line (HeLa) Human TMEM231 1:3~1:6 Negative Online Inquiry
KO13198 TMEM231 Knockout cell line (HCT 116) Human TMEM231 1:2~1:4 Negative Online Inquiry
KO13199 TMEM231 Knockout cell line (HEK293) Human TMEM231 1:3~1:6 Negative Online Inquiry
KO13200 TMEM231 Knockout cell line (A549) Human TMEM231 1:3~1:4 Negative Online Inquiry

Background

TMEM231 Gene Knockout Cell Lines are specialized cellular models designed to investigate the functional role of the TMEM231 gene, which is implicated in various cellular processes, including protein trafficking and ciliogenesis. These cell lines have been precisely engineered to exhibit a complete knockout of the TMEM231 gene, enabling researchers to study its absence and the resultant phenotypic changes at the molecular, cellular, and tissue levels.

The key function of these knockout cell lines is to provide an experimental platform to explore the biological pathways governed by TMEM231. By utilizing CRISPR/Cas9 gene editing technology, these cell lines allow for the in-depth analysis of TMEM231's involvement in disease states, particularly in conditions related to ciliopathy and cellular communication. The absence of TMEM231 can reveal insights into its role in organelle dynamics, such as endosomal sorting and cilia morphology, which are critical for understanding developmental biology and pathophysiology.

Scientifically, TMEM231 Gene Knockout Cell Lines hold substantial importance in both research and clinical settings. They serve as valuable tools for drug discovery, allowing scientists to screen for compounds that may modulate TMEM231-related pathways, and can also facilitate studies related to genetic disorders, paving the way for therapeutic interventions.

Compared to alternative models, such as traditional wild-type cell lines, these knockout lines provide a clearer understanding of genotypic influences on phenotypic outcomes. They are superior for untangling complex genetic interactions and validating potential therapeutic strategies, thus offering researchers a robust and reliable resource.

For researchers and clinicians, the TMEM231 Gene Knockout Cell Lines represent a progressive tool that can accelerate scientific discovery and contribute to advancements in personalized medicine. With our commitment to innovation and quality, we provide expertise and resources that ensure the reliability of outcomes derived from our product offerings, empowering your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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