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TMEM187 Knockout Cell Lines

Gene: TMEM187

Official Full Name: transmembrane protein 187provided by HGNC

Gene Summary: This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variant encoding the same protein has been found, but its biological validity is not determined. [provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01473 TMEM187 Knockout cell line (HEK293) Human TMEM187 1:3~1:6 Negative Online Inquiry
KO01479 TMEM187 Knockout cell line(K-562) Human TMEM187 1:3-1:5 Negative Online Inquiry
KO13210 TMEM187 Knockout cell line (HeLa) Human TMEM187 1:3~1:6 Negative Online Inquiry
KO13211 TMEM187 Knockout cell line (HCT 116) Human TMEM187 1:2~1:4 Negative Online Inquiry
KO13212 TMEM187 Knockout cell line (A549) Human TMEM187 1:3~1:4 Negative Online Inquiry

Background

TMEM187 Gene Knockout Cell Lines are genetically modified cellular models that have undergone targeted gene disruption, specifically focusing on the TMEM187 gene. This biotechnological advancement allows for precise investigation into the role of TMEM187 in various biological processes. The knockout mechanism is typically achieved through the CRISPR/Cas9 genome editing technology, which enables researchers to create homozygous or heterozygous knockout models that facilitate the study of gene function and its downstream effects.

Key functions of TMEM187 Gene Knockout Cell Lines involve elucidating the gene's role in cellular mechanisms such as signal transduction, cellular communication, and metabolic pathways. Researchers can manipulate various experimental conditions to observe how the absence of TMEM187 affects cellular behavior, providing insights into its contributions to health and disease, particularly in areas such as cancer research and neurodegeneration. The ability to create a cell line that models the deficient state of TMEM187 opens new avenues for targeted drug discovery and therapeutic interventions.

The scientific importance of these cell lines lies in their potential applications across both basic research and clinical settings. They can be used for high-throughput screening of drug candidates, functional genomics, and the development of personalized medicine approaches. By utilizing these models, researchers can gain a deeper understanding of disease mechanisms that may be otherwise obscured in heterogeneous systems.

Compared to alternative models, TMEM187 Gene Knockout Cell Lines offer unparalleled specificity and reproducibility. They eliminate background variations associated with endogenous gene expression levels, providing clearer insights into the functional impact of gene loss. This specificity is critical when assessing candidate therapeutic approaches targeted at pathways influenced by TMEM187.

For researchers and clinicians seeking to bridge the gap between genomics and practical applications, TMEM187 Gene Knockout Cell Lines represent a critical tool that enhances experimental fidelity and contributes to advancing our understanding of complex biological systems. As a leader in genetic modification technologies, our company is committed to providing high-quality, reliable cell lines that empower scientific discovery and innovation in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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