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SRSF12 Knockout Cell Lines

Gene: SRSF12

Official Full Name: serine and arginine rich splicing factor 12provided by HGNC

Gene Summary: Enables RNA binding activity. Involved in mRNA 5'-splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26394 SRSF12 Knockout cell line (HEK293) Human SRSF12 1:3~1:6 Negative Online Inquiry
KO26395 SRSF12 Knockout cell line (A549) Human SRSF12 1:3~1:4 Negative Online Inquiry

Background

SRSF12 Gene Knockout Cell Lines are meticulously engineered mammalian cell systems created to study the functional role of the SRSF12 gene, known for its involvement in pre-mRNA splicing and gene expression regulation. These knockout lines are generated using advanced CRISPR-Cas9 gene editing technology, which enables precise deletion of the SRSF12 gene, allowing researchers to investigate the consequences of its absence on cellular behavior and gene regulatory networks.

The primary function of these cell lines lies in their capacity to model diseases associated with dysregulated splicing and contribute to the understanding of mechanisms underlying various biological processes. By eliminating SRSF12, scientists can delve into the intricate roles this splicing factor plays in cellular proliferation, differentiation, and response to stress, thereby elucidating its impact on cancer progression and other pathologies.

Scientifically, SRSF12 Gene Knockout Cell Lines offer invaluable insights that can enhance research in genetics, molecular biology, and therapeutic development. They are particularly beneficial in clinical settings for the identification of novel splicing-related biomarkers and potential therapeutic targets. This product addresses a pressing need in the scientific community for robust models that accurately reflect the absence of specific splicing factors, enabling higher fidelity in experimental data and fostering reproducibility in research findings.

One distinguishing advantage of our SRSF12 Gene Knockout Cell Lines is their comprehensive validation and characterization, which ensures consistent biology across batches. Unlike other knockout models, our lines are tested for genomic integrity and phenotypic expression, providing confidence in the data generated. Additionally, they can be easily integrated into existing workflows, allowing researchers to maximize throughput and efficiency in their studies.

In a rapidly evolving research landscape, SRSF12 Gene Knockout Cell Lines serve as a critical resource for investigators seeking to advance our understanding of gene regulation and its implications for human health. With a commitment to exceptional quality and scientific rigor, our company prides itself on being a leader in biological product development, equipping researchers and clinicians with the tools they need to make groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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