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SKAP1 Knockout Cell Lines

Gene: SKAP1

Official Full Name: src kinase associated phosphoprotein 1provided by HGNC

Gene Summary: This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00866 SKAP1 Knockout cell line(HCT 116) Human SKAP1 1:2~1:4 Negative Online Inquiry

Background

SKAP1 Gene Knockout Cell Lines represent a significant advancement in functional genomics, providing researchers with a robust tool for investigating the role of the SKAP1 gene in cellular processes. These cell lines are engineered to express a genetic modification that disrupts the normal function of the SKAP1 gene, enabling the study of its contributions to immune signaling pathways and broader physiological responses.

The key function of these knockout cell lines is their ability to allow for the dissection of SKAP1's role in T-cell activation and signaling. By utilizing CRISPR/Cas9 genome editing technology, the SKAP1 Gene Knockout Cell Lines ensure a precise deletion of the SKAP1 gene, which offers insights into how this protein interacts with other cellular components during immune responses. This mechanism facilitates the assessment of T-cell receptor (TCR) signaling and can elucidate the pathways through which SKAP1 influences cell proliferation, differentiation, and cytokine production.

The scientific importance of SKAP1 Gene Knockout Cell Lines is underscored by their diverse applications in both research and clinical settings. They serve as valuable models for studying immune disorders, autoimmune diseases, and cancer biology. Researchers can utilize these cell lines to explore therapeutic targets, contributing to the development of innovative treatments and diagnostic tools.

In comparison to alternatives such as RNA interference or non-specific inhibitors, SKAP1 Gene Knockout Cell Lines provide a more stable and permanent solution with fewer off-target effects. This specificity enhances the reliability of experimental outcomes, allowing for more rigorous scientific inquiries.

For researchers and clinicians committed to advancing our understanding of immune function and its implications for health and disease, SKAP1 Gene Knockout Cell Lines offer an unparalleled resource. Their ability to facilitate precise genetic studies positions them as an essential asset in both academic and clinical research environments.

Our company, with extensive expertise in genetic engineering and cell line development, is dedicated to providing high-quality biological products. We strive to support the scientific community by offering innovative solutions that advance biomedical research and therapy development.

Please note that all services are for research use only. Not intended for any clinical use.

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