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SERPINB8 Knockout Cell Lines

Gene: SERPINB8

Official Full Name: serpin family B member 8provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. [provided by RefSeq, Jan 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36078 SERPINB8 Knockout cell line (HeLa) Human SERPINB8 1:3~1:6 Negative Online Inquiry
KO36079 SERPINB8 Knockout cell line (HCT 116) Human SERPINB8 1:2~1:4 Negative Online Inquiry
KO36080 SERPINB8 Knockout cell line (HEK293) Human SERPINB8 1:3~1:6 Negative Online Inquiry
KO36081 SERPINB8 Knockout cell line (A549) Human SERPINB8 1:3~1:4 Negative Online Inquiry

Background

SERPINB8 Gene Knockout Cell Lines represent a powerful tool for biologists studying the role of the SERPINB8 gene in various cellular processes. These engineered cell lines are generated through precise genome-editing techniques, specifically CRISPR-Cas9 technology, to create specific mutations that inactivate the SERPINB8 gene, allowing researchers to investigate the function of this protein in intricate biological pathways.

The SERPINB8 gene encodes a member of the serine protease inhibitor family, which plays a critical role in regulating proteolytic activity within the cellular environment. By utilizing these knockout cell lines, scientists can elucidate the mechanistic roles of SERPINB8 in processes such as apoptosis, cell migration, and immune responses. The absence of SERPINB8 facilitates the examination of downstream effects and compensatory mechanisms that occur when protease regulation is disrupted, providing insights that are crucial for understanding pathological conditions, including cancer and autoimmune diseases.

The scientific significance of SERPINB8 Gene Knockout Cell Lines extends beyond basic research—they hold promise in translational studies and potential therapeutic interventions. Researchers in both academic and clinical settings can use these cell lines to validate drug targets, identify biomarkers for disease progression, or assess the efficacy of novel therapies aimed at modulating protease activity.

In comparison to traditional cell lines, our SERPINB8 knockout models exhibit a superior specificity and reproducibility, allowing for more accurate interpretations of experimental data. The convenience of having a ready-to-use model system designed to study gene function streamlines research processes and significantly reduces the time required for experiment setup.

Investing in SERPINB8 Gene Knockout Cell Lines means equipping your laboratory with a resource that enhances experimental precision and opens avenues for groundbreaking discoveries in cell biology. Our company specializes in providing high-quality genetic models backed by extensive expertise in genome editing, ensuring that you receive reliable products that meet the rigorous demands of modern biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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