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RHCG Knockout Cell Lines

Gene: RHCG

Official Full Name: Rh family C glycoproteinprovided by HGNC

Gene Summary: Enables several functions, including ammonium channel activity; ankyrin binding activity; and carbon dioxide transmembrane transporter activity. Involved in ammonium transmembrane transport; intracellular monoatomic ion homeostasis; and transepithelial ammonium transport. Located in apical plasma membrane and basolateral plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04756 RHCG Knockout cell line (A549) Human RHCG 1:3~1:4 Negative Online Inquiry

Background

RHCG Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the rhombic-like carbonic anhydrases, essential enzymes involved in pH regulation and bicarbonate transport. These knockout cell lines have had the RHCG gene precisely deleted, allowing researchers to investigate the functional roles of this gene in cellular physiology and pathophysiology without interference from its normal activity.

The primary function of RHCG Gene Knockout Cell Lines lies in their capability to elucidate the physiological impacts of RHCG deficiency. By utilizing CRISPR-Cas9 technology, these cell lines provide a reliable platform for studying the consequences of gene knockout at both the cellular and molecular levels. Researchers can investigate changes in ion transport, acid-base balance, and cellular responses under various physiologic conditions, which are critical for understanding diseases related to dysregulated bicarbonate transport and related disorders.

The scientific importance of RHCG Gene Knockout Cell Lines extends to both basic research and clinical applications. In laboratory settings, these cell lines serve as invaluable tools in drug discovery and development, enabling the identification of potential therapeutic targets for conditions such as metabolic disorders and respiratory diseases. Additionally, their application in studying epithelial transport mechanisms enhances our understanding of genetic variations in human populations that may influence fitness and disease susceptibility.

Compared to traditional methods for gene editing, RHCG Gene Knockout Cell Lines stand out for their precision and reliability. Other gene manipulation techniques often result in incomplete or off-target modifications, which may compromise data integrity. In contrast, our cell lines offer a fully characterized genetic background, reducing variability in experimental results and enabling reproducible research findings.

For researchers, clinicians, and biopharmaceutical companies, RHCG Gene Knockout Cell Lines present a unique and indispensable asset. Their operational simplicity, combined with the depth of insights they provide into molecular mechanisms, makes them essential for advancing our understanding of complex biological processes.

Our company brings extensive expertise in the development of genetically modified cell lines tailored to meet the highest standards of scientific research. With a commitment to innovation and quality, we empower the scientific community to accelerate discoveries that can lead to new therapeutic strategies and improved clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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