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RASD1 Knockout Cell Lines

Gene: RASD1

Official Full Name: ras related dexamethasone induced 1provided by HGNC

Gene Summary: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22315 RASD1 Knockout cell line (HEK293) Human RASD1 1:3~1:6 Negative Online Inquiry

Background

RASD1 Gene Knockout Cell Lines are a pioneering biological product designed for advanced research into the RAS-Related D1 protein’s roles in cellular signaling pathways. These genetically modified cell lines have been meticulously developed to lack expression of the RASD1 gene, allowing researchers to explore the protein’s function in maintaining cellular homeostasis, regulating hormone responses, and deciphering its involvement in various pathophysiological conditions, including cancer and metabolic disorders.

The primary mechanism of the RASD1 Gene Knockout Cell Lines involves the use of CRISPR-Cas9 technology to precisely edit the genomic DNA, resulting in the ablation of RASD1 expression. This knockout model enables scientists to investigate the downstream effects of RASD1 signaling on key cellular processes such as proliferation, differentiation, and apoptosis. By employing these cell lines, researchers can better understand how manipulations in RASD1 expression influence critical pathways, thus driving forward both basic biological research and potential therapeutic strategies.

The scientific importance of RASD1 Gene Knockout Cell Lines is underscored by their broad applications in both research and clinical settings. They serve as invaluable tools for drug discovery, functional genomics, and the study of disease models. The insights gained from experiments utilizing these knockout lines pave the way for the identification of novel therapeutic targets and biomarkers, particularly for diseases where RASD1 is implicated.

In comparison to alternative models, RASD1 Gene Knockout Cell Lines offer distinct advantages, including improved specificity and reproducibility. Unlike transient transfection methods, these stable cell lines provide a consistent platform for longitudinal studies, enabling researchers to obtain more reliable data over time. Furthermore, their ability to mimic in vivo-like conditions allows for more physiologically relevant conclusions.

Ultimately, RASD1 Gene Knockout Cell Lines represent an indispensable resource for researchers and clinicians seeking to unravel the complexities of the RASD1 signaling pathway. By choosing this product, users can enhance their research efficacy and contribute to the advancement of innovations in therapeutic development. Our company, a leader in genetic engineering and biological product development, is committed to providing high-quality, scientifically-validated tools that empower research excellence and support transformative discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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