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RASAL1 Knockout Cell Lines

Gene: RASAL1

Official Full Name: RAS protein activator like 1provided by HGNC

Gene Summary: The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08976 RASAL1 Knockout cell line (HCT 116) Human RASAL1 1:2~1:4 Negative Online Inquiry

Background

RASAL1 Gene Knockout Cell Lines are advanced biological products designed for the in-depth study of the RAS association domain family member 1 (RASAL1) gene, which plays a critical role in regulating cellular signal transduction pathways. These knockout cell lines are engineered to disrupt the RASAL1 gene, allowing researchers to investigate the gene's function and its implications in various biological processes, particularly those related to cancer and cellular proliferation.

The key mechanism of RASAL1 knockout cell lines is based on CRISPR/Cas9 technology, a powerful genome editing tool that enables precise genetic modifications. By effectively inactivating the RASAL1 gene, these cell lines provide an ideal system for elucidating the pathways involved in tumorigenesis and understanding how alterations in RAS signaling contribute to malignancies. Researchers can observe phenotypic changes, assess proliferation rates, and dissect signaling pathways in a controlled environment, leading to invaluable insights into therapeutic targets and potential interventions.

In the scientific arena, these RASAL1 knockout cell lines are paramount for both fundamental research and translational medicine. They support studies related to oncogenesis, signal transduction, and the identification of novel drug targets, which are essential for developing innovative cancer treatments. Additionally, these cell lines can be utilized in pharmacological studies, providing a platform for testing the efficacy of new compounds in modulating RAS signaling pathways.

Unique advantages of RASAL1 Gene Knockout Cell Lines include their high specificity, reproducibility, and ease of use compared to alternative models. While traditional approaches such as shRNA or siRNA may offer temporary knockdown, the complete knockout phenotype allows for more comprehensive assessments of gene function. This product empowers researchers with reliable models that reflect the true biological absence of RASAL1, enhancing the validity of experimental results.

For researchers and clinicians seeking to advance their understanding of RAS signaling and its implications in diseases, RASAL1 Gene Knockout Cell Lines represent an invaluable tool. Their precise gene editing, coupled with our commitment to quality and innovation, underscores our expertise in the realm of biological products, making us a preferred partner in cutting-edge scientific exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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