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PTTG1 Knockout Cell Lines

Gene: PTTG1

Official Full Name: PTTG1 regulator of sister chromatid separation, securinprovided by HGNC

Gene Summary: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04635 PTTG1 Knockout cell line (HeLa) Human PTTG1 1:3~1:6 Negative Online Inquiry
KO04636 PTTG1 Knockout cell line (HCT 116) Human PTTG1 1:2~1:4 Negative Online Inquiry
KO04637 PTTG1 Knockout cell line (HEK293) Human PTTG1 1:3~1:6 Negative Online Inquiry
KO04638 PTTG1 Knockout cell line (A549) Human PTTG1 1:3~1:4 Negative Online Inquiry

Background

PTTG1 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the biological implications of the PTTG1 gene, also known as the Pituitary Tumor-Transforming Gene 1. This gene plays a significant role in cell proliferation, apoptosis, and oncogenesis. Utilizing CRISPR-Cas9 or other gene-editing technologies, PTTG1 Knockout Cell Lines exhibit a complete loss of PTTG1 expression, allowing researchers to investigate the phenotype changes that occur in the absence of this crucial gene.

The primary function of these cell lines is to elucidate the mechanisms by which PTTG1 influences tumorigenesis and cancer progression. By knocking out the PTTG1 gene, scientists can effectively assess its role in cell cycle regulation, as well as its interactions with both oncogenic and tumor-suppressive pathways. This unique model provides invaluable insights into the etiology of various cancers, particularly pituitary adenomas and other malignancies, contributing significantly to the field of cancer research.

In clinical and research settings, PTTG1 Knockout Cell Lines are essential for the validation of therapeutic targets and the development of novel cancer treatments. By providing a controlled environment to study gene function, these cell lines enable researchers to perform high-throughput screenings, drug efficacy assessments, and mechanistic studies with unparalleled precision.

Compared to conventional cell lines or animal models, PTTG1 Genetic Knockout Cell Lines offer numerous advantages including reproducibility, ease of use, and the ability to explore gene function in a relevant cellular context. Their unique design minimizes variability, allowing for high confidence in experimental results, ultimately accelerating the pathway from research to clinical application.

For researchers and clinicians focused on cancer biology, the PTTG1 Gene Knockout Cell Lines represent a valuable addition to their toolkit. They can be effectively utilized in the investigation of tumor biology, therapeutic drug screening, and understanding cancer metastasis. Our company, a leader in the production of biologically relevant cell lines, is dedicated to advancing research with high-quality, reliable products as part of our extensive portfolio tailored to meet the needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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